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The transgenic non-human mammal to monitor changes in the concentration of calcium ions within the cell
The transgenic non-human mammal to monitor changes in the concentration of calcium ions within the cell
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机译:转基因非人类哺乳动物,监测细胞内钙离子浓度的变化
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摘要
In accordance with the present invention, transgenic non human incubation with a DNA encoding an exogenous reporter protein for monitoring changes in intracellular calcium ions and expressing the reporter protein in one or more non neuronal cells Method for producing transgenic non human mammal, method for detecting change in concentration of intracellular calcium ion using transgenic non human mammal, DNA having promoter activity for preparation, and DNA thereof Usage is provided. Non human mammals of the present invention include the DNA, epithelial tissue, connective tissue, adipose tissue, cartilage tissue, bone tissue, muscle tissue, oral tissue, blood tissue, bone marrow, circulatory organ, lymphatic organ, teeth, digestive tract, liver, gallbladder, pancreas, respiratory organ, urinary tract, genital organ, endocrine Any of the bioactive substances (e.g., drugs) or unknown functions in these tissues or organs are expressed in one or more tissues or organs selected from the group consisting of organs, sensory organs, and nailsIt can be used for pharmacological evaluation and activity evaluation of the dentin products.
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