首页> 外国专利> use of estradiolvalerat or estradiol in combination with dienogest for oral treatment of dysfunktionellen uterine bleeding in unity with oral contraception

use of estradiolvalerat or estradiol in combination with dienogest for oral treatment of dysfunktionellen uterine bleeding in unity with oral contraception

机译:雌二醇或雌二醇联合地诺孕酮联合口服避孕药口服治疗功能不全子宫出血的应用

摘要

Use of estradiol valerate with 17alpha -cyanomethyl-17-beta -hydroxyestra-4,9-diene-3-one for producing a multi-phase combination preparation for the oral therapy of the dysfunctional uterine bleeding in the form of oral contraceptives. The combination of estradiol valerate with dienogest comprises a first phase consisting of 2 daily dose units of estradiol valerate, a second phase consisting of 2 groups of daily dose units of the combination, where the first group contains 5 daily dose units and the second group contains 17 daily dose, and a third phase consisting of 2 daily dose units. Use of estradiol valerate with 17alpha -cyanomethyl-17-beta -hydroxyestra-4,9-diene-3-one (dienogest) for producing a multi-phase combination preparation for the oral therapy of the dysfunctional uterine bleeding, in the form of oral contraceptives. The combination of estradiol valerate with dienogest comprises a first phase consisting of 2 daily dose units of estradiol valerate at 3 mg, a second phase consisting of 2 groups of daily dose units, where the first group contains 5 daily dose units of a combination of 2 mg estradiol valerate and 2 mg of dienogest and the second group contains 17 daily dose units consisting of a combination of 2 mg of estradiol valerate and 3 mg of dienogest, a third phase consisting of 2 daily dose units having 1 mg of estradiol valerate and an additional phase consisting of 2 daily dose units on a pharmaceutically harmless placebo. The entire daily dose units of the multi-phase combination corresponds to 28 days. ACTIVITY : Contraceptive; Gynecological. MECHANISM OF ACTION : None given.
机译:戊酸雌二醇与17α-氰基甲基-17-β-羟基estra-4,9-二烯-3-酮的用途,用于生产口服避孕药形式的功能失调性子宫出血的多相联合制剂。戊酸雌二醇与地诺孕的组合包括由2个日剂量单位的戊酸雌二醇组成的第一阶段,由2组日剂量单位的组合组成的第二阶段,其中第一组包含5个日剂量单位,第二组包含17个日剂量,第三阶段包含2个日剂量单位。戊酸雌二醇与17α-氰基甲基17-β-羟基雌4,9-二烯-3-酮(地诺孕)在制备多相联合制剂中的用途,用于口服治疗功能异常的子宫出血,形式为口服避孕药具。戊酸雌二醇与地诺孕的组合包括一个第一阶段,该阶段由2个每日剂量单位的戊酸雌二醇组成,剂量为3 mg,第二阶段由2组日剂量单位组成,其中第一组包含5个日剂量单位,两者合计2戊酸雌二醇和2毫克地诺孕酮,第二组包含17每日剂量单位,包括2毫克戊酸雌二醇和3毫克地诺孕的组合;第三阶段包括2个日剂量单位,其中含有1毫克戊酸雌二醇和在药学上无害的安慰剂上,由2个日剂量单位组成的其他阶段。多阶段组合的全部日剂量单位相当于28天。活动:避孕;妇科作用机理:未给出。

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