首页> 外国专利> METHOD OF PREDICTING RISK OF DEVELOPMENT OF ABNORMAL UTERINE BLEEDINGS IN PUBERTY PERIOD IN TEENAGE GIRLS

METHOD OF PREDICTING RISK OF DEVELOPMENT OF ABNORMAL UTERINE BLEEDINGS IN PUBERTY PERIOD IN TEENAGE GIRLS

机译:预测十几岁女孩气虚期子宫出血的发生风险的方法

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to gynecology, and can be used for prediction of risk of development of abnormal uterine bleedings in puberty period in teenage girls. For this purpose weight is determined (Ves), weight 45 kg and lower is designates as 1, from 46 to 48 kg - as 2, from 49 to 52 kg - as 3, from 53 to 62 kg - as 4; from 62 to 68 kg - as 5; 68 kg and higher- as 6. Height (Rost) is measured, height 154 cm and lower is designated as 1, from 155 to 157 cm - as 2; from 158 to 161 cm - as 3; from 162 to 170 cm - kas 4; from 171 to 173 cm - as 5; from 174 cm and higher - as 6. Pinch test (Proba) is carried out, negative test is designated as 1, positive - as 2. Varga index is determined, norm is designated as 1; moderate body weight reduction as 2; body weight deficit - as 3. In urine concentration of total hydroxyproline is determined in mcmol/l (OGOP); concentration of bound hydroxyproline in mcmol/l (SV-GOP) are determined. In blood concentration of luteinising hormone in mIU/ml (LG); concentration of estradiol in ng/ml (ESTROD); concentration of thyrotropic hormone in ng/ml (TTG); concentration of antibodies to thyroid peroxidase in unit/ml (AT-TPO) are determined. Obtained results of examination are substituted into mathematical prognostic models: Model 1= Ves*9.7489-Rost*2.4950+Proba*2.3133+Index*14.2906-SV-GOP*0.0437+OGOP*0.1088-LG*0.1261+ESTROD*0.2678+TTG*0.8120-AT-TPO*0.0338-47.8720; Model 2 =Ves* 10.3679-Rost*2.5602+Proba*4.4430+Index*16.2118-SV-GOP*0.0730+OGOP*0.1490-LG*0.8682+ESTROD*0.2128+TTG*1.4743-AT-TPO*0.1035-55.7844. From two obtained values the larger one is selected. If larger value is obtained in model 1, low risk of uterine bleedings development is predicted. If larger value is obtained in model 2, high risk is predicted.;EFFECT: method ensures increased accuracy of prediction of risk of abnormal uterine bleedings development in puberty period.;2 ex
机译:技术领域本发明涉及医学,即妇科,可用于预测青春期青春期子宫异常出血发生风险。为此,确定重量(Ves),将45公斤及以下的重量指定为1,从46到48公斤-作为2,从49到52公斤-作为3,从53到62公斤-作为4;从62到68公斤-5 68公斤及更高-6。测量身高(Rost),身高154 cm及以下表示为1,155至157 cm-2表示;从158到161厘米-3从162到170厘米-kas 4;从171到173厘米-5从174厘米及更高处开始-为6。进行捏缩测试(Proba),将阴性测试指定为1,将阳性测试指定为2。确定Varga指数,将范数指定为1;中度减轻体重为2;体重不足-为3。尿中总羟脯氨酸浓度以mcmol / l(OGOP)为单位;确定以mcmol / l(SV-GOP)为单位的结合羟脯氨酸的浓度。血液中黄体生成素的浓度,单位为mIU / ml(LG);雌二醇的浓度,单位为ng / ml(ESTROD);促甲状腺激素浓度,单位为ng / ml(TTG);确定抗甲状腺过氧化物酶抗体的浓度,单位/ ml(AT-TPO)。将获得的检查结果替换为数学预测模型:模型1 = Ves * 9.7489-Rost * 2.4950 + Proba * 2.3133 + Index * 14.2906-SV-GOP * 0.0437 + OGOP * 0.1088-LG * 0.1261 + ESTROD * 0.2678 + TTG * 0.8120-AT-TPO * 0.0338-47.8720;模型2 = Ves * 10.3679-Rost * 2.5602 + Proba * 4.4430 + Index * 16.2118-SV-GOP * 0.0730 + OGOP * 0.1490-LG * 0.8682 + ESTROD * 0.2128 + TTG * 1.4743-AT-TPO * 0.1035-55.7844。从获得的两个值中选择较大的一个。如果在模型1中获得较大的值,则可以预测发生子宫出血的风险较低。如果在模型2中获得较大的值,则可以预测为高风险。效果:该方法可确保提高青春期异常子宫出血发生风险的预测准确性。

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