METHOD OF EARLY PREDICTION OF SEPTIC COMPLICATIONS IN NEWBORNS WITH RESPIRATORY PATHOLOGY

• 1. 一种治疗新生儿败血症的中药及其制备方法 [P] . 中国专利： CN105770226A . 2016-07-20
• 2. 急性肾损伤早期预测方法及装置 [P] . 中国专利： CN113903458A . 2022-01-07
• 3. METHOD FOR USING GUARANTEED TIDAL VOLUME IN NEWBORNS WITH SEVERE RESPIRATORY PATHOLOGY, MANIFESTED BY RESPIRATORY FAILURE OF II-III SEVERITY [P] . RU2750841C1 . 2021-07-05

  机译： 新生儿用严重呼吸道理使用保证潮气体积的方法，表现为II-III严重程度的呼吸衰竭

• 4. METHOD FOR DETERMINING A GROUP WITH A RISK OF POSTOPERATIVE SEPTIC COMPLICATIONS OF PATIENTS WITH URGENT ABDOMINAL PATHOLOGY [P] . UA98855U . 2015-05-12

  机译： 急腹症患者的术后脓毒症并发症风险确定方法

• 5. DIAGNOSTIC TECHNIQUE FOR PURULENT-SEPTIC COMPLICATIONS IN NEWBORNS [P] . 俄罗斯专利： RU2484479C1 . 2013-06-10

  机译： 新生儿脓疱性并发症的诊断技术

• 1. Correlation of Inferior Vena Cava Respiratory Variability Index with Central Venous Pressure and Hemodynamic Parameters in Ventilated Pigs with Septic Shock [J] . LIU Xiao Lei, TAO Yong Kang, YAN Sheng Tao, 生物医学与环境科学（英文版） . 2013,第006期
• 2. The incidence of septic complications in newborns on extracorporeal membrane oxygenation is not affected by feeding route. [J] . Wertheim HF, Albers MJ, Piena-Spoel M, Journal of Pediatric Surgery: Official Journal of the Surgical Section of the American Academy of Pediatric, the British Association of Paediatric Surgeons, the American Pediatric Surgical Association, and the Canadian Association of Paediatric Surgeons . 2001,第10期
• 3. Oscillatory respiratory mechanics on the first day of life improves prediction of respiratory outcomes in extremely preterm newborns [J] . Chiara Veneroni, Linda Wallstr?m, Richard Sindelar, Pediatric Research . 2018,第3期
• 4. Investigation of urine proteome of preterm newborns with respiratory pathologies [J] . Starodubtseva Natalia L., Kononikhin Alexey S., Bugrova Anna E., Journal of proteomics . 2016,第Null期
• 5. Prediction of Radical Hysterectomy Complications for Cervical Cancer Using Computational Intelligence Methods [C] . Jacek Kluska, Maciej Kusy, Bogdan Obrzut International conference on artificial intelligence and soft computing;ICAISC 2012 . 2012
• 6. Machine Learning Methods for Septic Shock Prediction [D] . Darwiche, Aiman A. 2018
• 7. V2 Evaluation of risk prediction models for postoperative pulmonary complications in adults undergoing major abdominal surgery: A systematic review and external validation study of the REspiratory COmplications after abdomiNal surgery (RECON) cohort [O] . Omar Kouli 2021
• 8. Dip Slide Culture of Intraoperative Peritoneal Irrigation Fluid for Prediction of Septic Complication in Elective Colorectal Surgery [O] . 1988
• 9. Respiratory Pattern Variability Analysis Based on Nonlinear Prediction Methods. [R] . Domingo, L., Caminal, P., Giraldo, B. F., 2001

• 1. Acoustic measures of the cry characteristics of healthy newborns and newborns with pathologies [J] . Yasmina Kheddache ,Chakib Tadj . 生物医学工程（英文） . 2013,第8期
• 2. Histopathology of renal asphyxia in newborn piglets: Individual susceptibility to tubular changes [J] . Clara Gerosa ,Nicoletta Iacovidou ,Ioanna Argyri . 世界肾病学杂志：英文版 . 2015,第2期
• 3. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 4. Septic Superficial Femoral Vein Thrombophlebitis Causing Pulmonary Emboli and Respiratory Failure: Case Report and Review of the Literature [J] . Ziad Fayad ,Paul Guentert ,Erin Rissler . 临床医学国际期刊（英文） . 2019,第8期
• 5. 马上呼吸道疾病诊断方法 [C] . 王志 . 第四届中国兽医大会暨中国兽医发展论坛 . 2013
• 6. 新生儿败血症临床诊断方法探讨 [A] . 戈海延 . 2008