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首页> 外国专利> CYTOTOXIC LINEAR HETEROCYCLIC DERIVATIVES OF ANTHRACENEDIONE HAVING IN SIDE CHAIN CYCLIC DIAMINES, ACTIVE TOWARDS TUMOUR CELLS WITH MULTIDRUG RESISTANCE

CYTOTOXIC LINEAR HETEROCYCLIC DERIVATIVES OF ANTHRACENEDIONE HAVING IN SIDE CHAIN CYCLIC DIAMINES, ACTIVE TOWARDS TUMOUR CELLS WITH MULTIDRUG RESISTANCE

机译：蒽环二酮中具有蒽环二酮的细胞毒性线性杂环衍生物，对多药耐药肿瘤细胞有活性

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FIELD: chemistry.;SUBSTANCE: invention relates to anthracenedione derivatives which are suitable for therapy of oncological diseases, having the formula:; , where W is a fragment of a five-member heterocycle containing one or two heteroatoms selected from N, O or S, optionally substituted with alkyl, halogen; Y is a monocyclic diamine residue containing an exocyclic amine group, or a polycyclic diamine with bridging amine groups, which is a compound in which two amine groups are involved in formation of 4- or 6-member ring systems containing 2-6 carbon atoms and bonded by one, two or three bridging atoms, where Y is optionally substituted with one or more substitutes selected from alkyl, halogenalkyl, halogen, hydroxyl, hydroxyalkyl, carbamoyl and CO2R, where R denotes alkyl; X denotes alkylene, CO or SO2; n and m are independently range from 0 to 2; Z1 is selected from hydroxy, alkoxy -NH2, -NHR1, -NR1R2, where R1 and R2 denote alkyl, aminoalkylamino, halogen; Z2 is selected from hydroxy, alkoxy, fluorine.;EFFECT: obtaining novel anti-tumour compounds.;1 cl, 18 ex, 3 tbl
机译：发明领域本发明涉及适用于治疗肿瘤疾病的蒽二酮衍生物，其具有下式： ，其中W是包含一个或两个选自以下原子的五元杂环的片段N，O或S，任选地被烷基，卤素取代; Y是含有环外胺基的单环二胺残基或具有桥联胺基的多环二胺，其是其中两个胺基参与形成含有2-6个碳原子的4或6元环系统的化合物。由一个，两个或三个桥接原子键合，其中Y可选地被一个或多个选自烷基，卤代烷基，卤素，羟基，羟烷基，氨基甲酰基和CO 2 R的取代基取代，其中R表示烷基; X表示亚烷基，CO或SO 2 ; n和m独立地为0到2; Z 1 选自羟基，烷氧基-NH 2 ，-NHR 1 ，-NR 1 R 2 ，其中R 1 和R 2 分别表示烷基，氨基烷基氨基，卤素; Z 2 选自羟基，烷氧基，氟。效果：获得新型抗肿瘤化合物。1cl，18 ex，3 tbl

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