• 主题
高级搜索  >
历史搜索 清空历史
首页> 外国专利> FLUORENE DERIVATIVES, HAVING ANTIPROLIFERATIVE ACTIVITY, CELL DIFFERENTIATION MODULATORS, METHOD OF SLOWING DOWN TUMOUR CELL PROLIFERATION, METHOD OF INDUCING DIFFERENTIATION IN MOUSE MELANOMA CELLS

FLUORENE DERIVATIVES, HAVING ANTIPROLIFERATIVE ACTIVITY, CELL DIFFERENTIATION MODULATORS, METHOD OF SLOWING DOWN TUMOUR CELL PROLIFERATION, METHOD OF INDUCING DIFFERENTIATION IN MOUSE MELANOMA CELLS

机译：荧光衍生物，具有抗增殖活性，细胞分化调节剂，减缓肿瘤细胞增殖的方法，在小鼠黑素瘤细胞中诱导分化的方法

页面导航
  • 摘要
  • 著录项
  • 相似文献

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to substituted fluorene compounds and specifically to a compound of formula where R1 denotes a NH2-group or a Br atom; R2 denotes hydrogen or halogen; R3 is selected from the following group: oxygen, aminoalkyl group =N-alkyl, where alkyl C1-C12 (having normal or branched structure), aminoaryl group=N-aryl, where aryl: phenyl, naphthyl, aminoheteroaryl group=N-heteroaryl, where heteroaryl: pyridine, quinoline, phenylamine. The invention also relates to a method of slowing down proliferation of tumour cells, involving addition of an acceptable amount of an active compound of formula (1) into the medium, and to a method of inducing differentiation in mouse melanoma cells B16-F10.;EFFECT: novel compounds which can be active agents which inhibit tumour proliferation and activate differentiation in mouse melanoma cells B16-F10 are obtained and described.;11 cl, 8 tbl, 11 dwg
机译：技术领域本发明涉及取代的芴化合物，尤其涉及式为<图像文件=“ 00000011.GIF” he =“ 28” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 51” / >其中R 1 表示NH 2 -基团或Br原子; R 2 表示氢或卤素; R 3选自以下基团：氧，氨基烷基= N-烷基，其中烷基C 1 -C 12 （具有正构或支链结构），氨基芳基= N -芳基，其中芳基：苯基，萘基，氨基杂芳基基团＝ N-杂芳基，其中杂芳基：吡啶，喹啉，苯胺。本发明还涉及减慢肿瘤细胞增殖的方法，包括向培养基中加入可接受量的式（1）活性化合物，以及在小鼠黑素瘤细胞B16-F10中诱导分化的方法。效果：获得并描述了可以作为抑制小鼠黑色素瘤细胞B16-F10肿瘤增殖并激活分化的活性剂的新型化合物; 11 cl，8 tbl，11 dwg

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号