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RECOMBINANT COI HERPESVIRUS (KHV) OR HERPESVIRUS 3 CARP FAMILY (CYHV-3) AND VACCINE FOR PREVENTION OF A DISEASE CAUSED BY KHV / CYHV-3 IN CYPRINUS CARPIO OR CYPRIUS CAR
RECOMBINANT COI HERPESVIRUS (KHV) OR HERPESVIRUS 3 CARP FAMILY (CYHV-3) AND VACCINE FOR PREVENTION OF A DISEASE CAUSED BY KHV / CYHV-3 IN CYPRINUS CARPIO OR CYPRIUS CAR
1. Recombinant koi herpesvirus (KHV) or herpesvirus 3 family of cyprinids (CyHV-3), which is immunogenic for fish, preferably for carps, more preferably for Cyprinus carpio. ! 2. The recombinant koi herpesvirus according to claim 1, which has the ability to confer immunity to fish, preferably carps, more preferably Cyprinus carpio, against a disease caused by herpesvirus koi (KHV) or herpesvirus 3 family of cyprinids (CyHV-3). ! 3. Recombinant koi herpes virus according to claim 1, which is deficient in viral genes in an amount of one or more that are not necessary for replication. ! 4. Recombinant koi herpes virus according to claim 1, which is deficient in at least one gene that contributes to virulence. ! 5. Recombinant koi herpes virus according to any one of claims 1 to 4, which is deficient in at least one gene that promotes virulence selected from the group consisting of the thymidine kinase gene, ORF12: the putative tumor necrosis factor receptor gene (TNF), ORF 16: putative G-protein coupled gene (GPCR), ORF 134: putative homolog gene for interleukin 10, ORF140: putative thymidylate kinase gene, or any combination thereof. ! 6. Recombinant koi herpes virus according to any one of claims 1 to 4, which is deficient in the viral gene of thymidine kinase and at least one additional gene that contributes to virulence selected from the group consisting of ORF12: putative receptor gene for tumor necrosis factor (TNF), ORF 16: putative G-protein coupled receptor gene (GPCR), ORF 134: putative homologue gene for interleukin 10, ORF140: presumptive
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