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APPLICATION OF SUBSTANCES FOR THE TREATMENT OF VISION LOSS IN PEOPLE WITH A DEAF AND OTHER DEGENERATIVE EYE DISEASES

机译:该物质在聋人和其他变性眼病患者中治疗视力丧失的应用

摘要

1. The use of a peptide containing the amino acid sequence XY or YX, where X is an aromatic amino acid, and Y is one or more additional amino acids other than glycine, and this peptide has at least 2 amino acid residues and less than 15 amino acid residues, to obtain a medicament for the prevention and treatment of an ocular condition associated with toxicity of β-amyloid (Aβ), wherein the formation of Aβ and / or the appearance of said Aβ is inhibited. ! 2. The use according to claim 1, where this condition is selected from the group consisting of primary angle-closure glaucoma, secondary open-angle glaucoma, open-angle glaucoma, steroids-induced glaucoma, traumatic glaucoma, pigmentary dispersion syndrome, pseudoexfoliation syndrome, secondary closed-angle glaucoma, neovascular glaucoma, and glaucoma associated with age-related macular degeneration, diabetic retinopathy, optic nerve degenerative neuropathy, and ocular pathologies characterized by progressive loss of vision, leading ultimately to blindness. ! 3. The use of the peptide according to claim 1 in combination with at least one additional pharmaceutical agent that is effective in treating this ocular condition, where this combination of the peptide according to claim 1 and at least one additional pharmaceutical agent is effective in treating this condition . ! 4. The use according to claim 3, in which this at least one additional pharmaceutical agent is a drug administered for the treatment of eye diseases, and contains
机译:1.含有氨基酸序列XY或YX的肽的用途,其中X是芳香族氨基酸,Y是除甘氨酸以外的一个或多个其他氨基酸,并且该肽具有至少2个氨基酸残基且少于15个氨基酸残基,以获得用于预防和治疗与β-淀粉样蛋白(Aβ)的毒性有关的眼部疾病的药物,其中Aβ的形成和/或所述Aβ的出现被抑制。 ! 2.根据权利要求1的用途,其中该病症选自原发性闭角型青光眼,继发性开角型青光眼,开角型青光眼,类固醇诱发的青光眼,创伤性青光眼,色素弥散综合症,假性剥脱综合症,继发性闭角型青光眼,新生血管性青光眼和青光眼,与年龄相关的黄斑变性,糖尿病性视网膜病变,视神经变性神经病变以及以逐渐进行性视力丧失为特征的眼部病变,最终导致失明。 ! 3.根据权利要求1的肽与至少一种有效治疗该眼病的另外的药物组合的用途,其中根据权利要求1的肽与至少一种另外的药剂的这种组合对治疗该眼病是有效的。这种情况。 ! 4.根据权利要求3的用途,其中该至少一种另外的药物是用于治疗眼病的药物,并且包含

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