首页> 外国专利> DERIVATIVE acyl hydrazide, METHOD FOR INHIBITION, CONTROL AND / OR MODULATION OF FORMING OR BINDING PROTEINS ADDL (OPTIONS) METHOD FOR INHIBITION, CONTROL AND / OR MODULATION INDUCED BY THEM neuronal dysfunction (VARIANTS) AND A METHOD FOR TREATING DISEASES ASSOCIATED WITH ABOVE DYSFUNCTION (VARIANTS) AND METHOD enhancing cognitive function

DERIVATIVE acyl hydrazide, METHOD FOR INHIBITION, CONTROL AND / OR MODULATION OF FORMING OR BINDING PROTEINS ADDL (OPTIONS) METHOD FOR INHIBITION, CONTROL AND / OR MODULATION INDUCED BY THEM neuronal dysfunction (VARIANTS) AND A METHOD FOR TREATING DISEASES ASSOCIATED WITH ABOVE DYSFUNCTION (VARIANTS) AND METHOD enhancing cognitive function

机译：衍生物酰肼，抑制，控制和/或调节形成或结合的蛋白质ADDL的方法（选择），抑制，控制和/或调节由其神经元功能障碍（变异）引起的方法和治疗与ABO相关的疾病的方法增强认知功能的变体和方法

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摘要

Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ß1-42 oligomers from amyloid ß1-42 monomers using acylhydrazidecompounds. Also disclosed are methods of treating a patient suffering from diseases associated with the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ß1-42 oligomers using acylhydrazidecompounds.

机译：公开了使用酰基酰肼化合物抑制，调节和/或调节由淀粉状β1-42单体形成的可溶性，球形，非原纤维，神经毒性淀粉状β1-42寡聚物的方法。还公开了使用酰肼化合物治疗患有与形成可溶性，球形，非原纤维，神经毒性淀粉样β1-42寡聚物有关的疾病的患者的方法。

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公开/公告号RU2010104039A

专利类型
公开/公告日2011-08-20

原文格式PDF
申请/专利权人 ЭЙКЬЮМЕН ФАМЭСЬЮТИКЛЗ ИНК. (US);
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申请/专利号RU20100104039
发明设计人 БХАГАТ НИКХИЛ (IN);ВАН ЦЗЯНЬ (US);ГАУЭР УИЛЬЯМ Ф. (US);ЗИМБОУЭ ДЕЙВИД Е. (US);КРАФФТ ГРАНТ А. (US);ЛУК ГЭРИ ЧАРЛЬЗ (US);ПОЛОЗОВ АЛЕКСАНДР МИХАЙЛОВИЧ (RU);ПРЭЙ ТОДД (US);ШУЛЬТЦ ЛОРИ (US);
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申请日2008-07-11
分类号A61K31/15;
国家 RU
入库时间 2022-08-21 17:48:55

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