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QUANTITATIVE DETERMINATION OF URINE IN risedronate SPE / LC-MS / MS

机译:定量测定瑞斯膦酸盐SPE / LC-MS / MS中的尿液

摘要

FIELD: medicine.;SUBSTANCE: invention concerns a method of SPE/LC-MS/MS for urine risedronate evaluation. The method involves: a) adding an internal standard solution to an urine sample; b) applying the urine sample on a processed chromatographic column followed by risedronate elution in vacuum; e) evaporating the eluted solution and dissolving for preparing a sample in the form of mixed risedronate and the internal standard; f) analysing the mixture sample in a system of high-pressure liquid chromatography - mass spectrometry/mass spectrometry (LC-MS/MS).;EFFECT: provided risedronate evaluation in the urine sample.;16 cl, 4 tbl, 6 dwg
机译:技术领域:本发明涉及一种SPE / LC-MS / MS用于尿液利塞膦酸盐评估的方法。该方法包括:a)向尿液样品中添加内标溶液; b)将尿液样品加到处理过的色谱柱上,然后在真空中进行利塞膦酸盐洗脱; e)蒸发洗脱液并溶解,以制备利塞膦酸盐和内标混合的形式制备样品; f)在高压液相色谱-质谱/质谱(LC-MS / MS)系统中分析混合物样品;效果:在尿液样品中提供了利塞膦酸盐评估; 16 cl,4 tbl,6 dwg

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