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Atraumatic STRIP WOUND CLEANSING OF PROLONGED with polymeric macroporous hydrogel 'HELIOS'

机译:聚合物大孔水凝胶“ HELIOS”的无创条带伤口清洁效果显着

摘要

The inventive atraumatic wound-cleansing long acting polymer hydrogel dressing is used for treating necrotic septic wounds of various etiology and consists of thee layers. The first healing layer applicable to a wound is embodied in the form of a dialdehyde cellulose provided with trypsin and lysozyme ferments co-immobilised thereon. The second layer is embodied in the form of a hydrogel plate which is based on acrylic polymers, for example, polyacrylamide dried to residual moisture of 6%. The third protective-and-absdorbingis layer is embodied in the form of a non-woven material which is based on ultrathin fibres and is covered on both sides with a perforated polyethylene film, wherein the surface area of the pores of the lower polyethylene layer is by three times greater than the thickness of the top layer. The dry dressing is packed in two-layer polyethylene packages is sterilised by means of gamma-radiation the dose of which is of 25 kGy. Prior to application, the dressing is humidified, thereby providing the healing layer with a high specific activity. The inventive dressing is characterised in that it can be applied to a wound for four days. Said dressing removes detritus from the wound and also accelerates reparative processes. The healing and hydrogel layers are constantly humid, thereby making the dressing highly atraumatic.
机译:本发明的无创伤口清洁长效聚合物水凝胶敷料用于治疗各种病因的坏死性败血性伤口,并由这些层组成。适用于伤口的第一愈合层以二醛纤维素的形式体现,该二醛纤维素具有固定在其上的胰蛋白酶和溶菌酶发酵液。第二层以水凝胶板的形​​式体现,该水凝胶板基于丙烯酸聚合物,例如干燥至残留水分为6%的聚丙烯酰胺。第三保护和吸收层以无纺材料的形式实现,该材料基于超细纤维并且在两侧均覆盖有多孔聚乙烯膜,其中下部聚乙烯层的孔的表面积为比顶层的厚度大三倍将干敷料包装在两层聚乙烯包装中,并通过伽玛射线灭菌,剂量为25 kGy。在施用之前,将敷料弄湿,从而为愈合层提供高比活性。本发明的敷料的特征在于它可以在伤口上施用四天。所述敷料从伤口去除碎屑并且还加速修复过程。愈合层和水凝胶层始终湿润,因此使敷料具有高度的无创伤性。

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