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首页> 外国专利> Peptide pharmaceutical compositions and drugs on its base, method of treatment and / or prevention of diabetes or a condition associated with obesity, a method of reducing appetite, reduced food intake, a decrease in caloric intake, a decrease in body weight and increase in costs ENERGY

Peptide pharmaceutical compositions and drugs on its base, method of treatment and / or prevention of diabetes or a condition associated with obesity, a method of reducing appetite, reduced food intake, a decrease in caloric intake, a decrease in body weight and increase in costs ENERGY

机译：以其为基础的肽类药物组合物和药物，治疗和/或预防糖尿病或与肥胖有关的疾病的方法，食欲降低，食物摄入减少，热量摄入减少，体重减轻和成本增加的方法能源

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1. A peptide characterized by a sequence of amino acids selected from the group consisting of! Haa1 Haa2 Haa3 Gly4 Thr5 Phe6 Thr7 Ser8 Asp9 Tyr10 Ser11 Lys12 Tyr13 Leu14 Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Haa21 Xaa22 Xaa23 Xaa24 Trp25 Leu26 Xaa27 Xaa28 Xaaaaaaaaaaaaaaaa ! where Haa1 is His1 or D-His1,! Haa2 is Ser2 or Ala2,! Xaa3 is Gln3 or Asp3; ! Haa15 Haa16 Haa17 Haa18 Haa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24 is:! Glu15 Glu16 Glu17 Leu 18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24,! Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24,! Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24,! Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24,! Glu15 Glu16 Glu17 Iie18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24,! Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24,! Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24,! Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24,! Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24,! Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24,! Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24,! Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24,! Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24,! Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24,! Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 or! Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24; ! Xaa27 Xaa28 Xaa29 Haa30 Haa31 Haa32 is! Lys27 Asn28 Ala29 Gly30 Pro31 Ser32! or Lys27 Asn28 Gly29 Gly30 Pro31 Ser32,! or the above peptide, in which the Asn34 residue is replaced by Asp34,! or the above peptide, in which Xaa3 is Glu3. ! 2. The peptide according to claim 1, in which! Haa1 Haa2 Haa3 is! His1 Ser2 Gln3,! D-His1 Ser2 Gln3,! D-His1 Ala2 Gln3 or! D-His1 Ala2 Asp3. ! 3. The peptide according to claim 1, having an amino acid sequence selected from the group comprising! His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala (SEQ ID NO: 1)! His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Glu Trp Leu Lys Asn Gly Gly Pro Ser Lys Asn Asn Ile Ala (SEQ ID NO: 2)! His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn
机译：1.一种肽，其特征在于选自以下组成的组的氨基酸序列： Haa1 Haa2 Haa3 Gly4 Thr5 Phe6 Thr7 Ser8 Asp9 Tyr10 Ser11 Lys12 Tyr13 Leu14 Xaa15 Xaa16 Xaa17 Xaa18 Xaa19 Xaa20 Haa21 Xaa22 Xaa23 Xaa24 Trp25 Leu26 Xaa27 Xaa28 Xaaaaaaaaaaaaaaaaaaaa！ Haa1是His1或D-His1！ Haa2是Ser2或Ala2 ，！ Xaa3是Gln3或Asp3; ！ Haa15 Haa16 Haa17 Haa18 Haa19 Xaa20 Xaa21 Xaa22 Xaa23 Xaa24是：！ Glu15 Glu16 Glu17 Leu 18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 ,! Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 ，！ Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 ,! Glu15 Glu16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24 ，！ Glu15 Glu16 Glu17 Iie18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 ,! Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 ，！ Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 ,! Glu15 Glu16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24 ，！ Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 ,! Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 ，！ Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24 ,! Glu15 Gln16 Glu17 Leu18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24 ，！ Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Glu24 ,! Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Leu23 Gln24 ，！ Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Glu24还是！ Glu15 Gln16 Glu17 Ile18 Val19 Lys20 Tyr21 Phe22 Ile23 Gln24; ！ Xaa27 Xaa28 Xaa29 Haa30 Haa31 Haa32是！ Lys27 Asn28 Ala29 Gly30 Pro31 Ser32！或Lys27 Asn28 Gly29 Gly30 Pro31 Ser32 ，！或上述肽，其中Asn34残基被Asp34取代！或上述肽，其中Xaa3是Glu3。 ！ 2.根据权利要求1的肽，其中！ Haa1 Haa2 Haa3是！ His1 Ser2 Gln3 ，！ D-His1 Ser2 Gln3 ，！ D-His1 Ala2 Gln3还是！ D-His1 Ala2 Asp3。 ！ 3.根据权利要求1所述的肽，其具有选自以下的氨基酸序列：他的Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Glu Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn Ile Ala（SEQ ID NO：1）！他的Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Glu Trp Leu Lys Asn Gly Pro Ser Lys Asn Asn Ile Ala（SEQ ID NO：2）！他的Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu Glu Leu Val Lys Tyr Phe Leu Gln Trp Leu Lys Asn Ala Gly Pro Ser Lys Asn Asn

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