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Fraction from stem bark of Vietnamese medicinal plant Garcinia oblongifoliaClusiaceae and compounds isolated therefrom having antioxidant and cytotoxic activities

机译：越南药用植物藤黄藤科的茎皮部分及其分离的具有抗氧化和细胞毒性活性的化合物

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extracted with 50% ethanol, Garcinia Oblique ronggi polyamic ( Garcinia oblongifolia) of the stem bark extract in dichloromethane (dichloromethane) is a single compound fraction was isolated from five kinds of, each Guti Peron F, Oblique ronggi Pauline A, Oblique Long gikeu non Santo, 30-epi-Cambodia was a long and benzoic ; Among them, Guti Peron F, Oblique ronggi Pauline A, 30- epi-Cambodian long is each IC _{in the DPPH test 50} value of 11.5 0.32, 10.3 0.27, 9.1 0.78 showed a higher antioxidant activity of ( M) (stronger than - tocopherol used as a positive control). Guti Peron F, oblique ronggi morpholine A, 30- epi-Cambodia long is also exhibited cytotoxic activity against cell lines A549 and A431. In particular, 30-epi-Cambodian long is eotneunde represent the strongest cytotoxic activity, IC ₅₀ values were 14.8 0.8 M, 14.3 0.5 M For the A431 cell line A549 cell lines with respect to ; The present invention is chemically Garcinia ronggi polyamic Oblique ( Garcinia oblongifolia) Guti Peron from the stem bark of F, Oblique Long gikeu non Santo, 30-epi-Cambodian acid to separate the long and is the first report to embellish. Long Oblique gikeu Santo also played and 30-epi-Cambodian embellish it separated from the natural long is the first invention. And Guti Peron F, Oblique ronggi Pauline A, 30- epi-Cambodian antioxidant and cytotoxic activity of the long, was found for the first time by the present invention

机译：用50％乙醇提取的藤黄果多糖（ Garcinia oblongifolia）的茎皮提取物在二氯甲烷（二氯甲烷）中是从5种中分离出的单一化合物级分，每种古提Peron F，斜草宝琳·A（Pauline A），斜长吉科·非桑托（Santo），30-上-柬埔寨，是长而苯甲酸;其中，Guti Peron F，Longi ronggi Pauline A，30- epi-Cambodian long在DPPH测试中的每个IC _{50 值分别为11.5 0.32、10.3 0.27、9.1 0.78，显示出更高的抗氧化活性（ M）（强于-生育酚用作阳性对照）。 Guti Peron F，斜荣基吗啉A，长30- Epi-Cambodia也对细胞系A549和A431表现出细胞毒活性。特别地，30-epi-Cambodian long以eotneunde表示最强的细胞毒活性，IC _{50 值相对于A431细胞系A549细胞系分别为14.8 0.8 M，14.3 0.5M。本发明是化学上的来自藤本植物藤黄多糖倾斜（ Garcinia oblongifolia） Guti Peron，它来自F，斜长gikeu non Santo的茎皮，30-表-柬埔寨酸以分开长的，并且是首次报道。装饰。 Long Oblique gikeu Santo也玩过这项技术，它与30-epi-Cambodian点缀于自然的long上，这是第一个发明。并且本发明首次发现古蒂·佩隆F，斜荣基宝琳A，30- Epi-柬埔寨抗氧化剂和长细胞毒性活性。}} 展开▼

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公开/公告号KR101005173B1

专利类型

公开/公告日2011-01-04

原文格式PDF

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申请/专利号KR20080014341

发明设计人 이범종;김맹섭;이관순;구경아;손은미;김은경;
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申请日2008-02-18

分类号A61K31/35;A61K31/352;A61K36/185;A61P35/00;

国家 KR

入库时间 2022-08-21 17:50:45

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机译：越南药用植物GARCINIA OBLONGIFOLIA（CLUSIACEAE）的茎皮部分及其分离的化合物具有抗氧化剂和细胞毒活性

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机译：含有从植物或从其制得的化合物中分离的抗氧化剂如迷迭香酸钠，可能引起氧化变质的物质。和用抗氧化剂处理该物质以赋予抗氧化剂保护的方法和方法

5. Compositions for the prevention or treatment of metabolic syndrome or complications thereof or antioxidant for containing extracts of Plectranthus hadiensis var. tomentosus Benth. ex E. Mey. Codd fractions or compounds isolated therefrom as an active ingredient [P] . 韩国专利： KR20170005776A . 2017-01-16

机译：用于预防或治疗代谢综合症或其并发症或抗氧化剂的组合物，其包含苦苣苔（Plectranthus hadiensis var）的提取物。 tomentosus Benth。前E. Mey。从其中分离的鳕鱼馏分或化合物作为有效成分

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