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METHOD OF CONTROLING TARGET SPECIFIC DRUG DELIVERY, TARGET SPECIFIC DRUG DELIVERY SYSTEM, AND TARGET NON-SPECIFIC LONG-ACTING DRUG DELIVERY SYSTEM
METHOD OF CONTROLING TARGET SPECIFIC DRUG DELIVERY, TARGET SPECIFIC DRUG DELIVERY SYSTEM, AND TARGET NON-SPECIFIC LONG-ACTING DRUG DELIVERY SYSTEM
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机译:目标特定药物输送的控制方法,目标特定药物输送系统和目标非特定长效药物输送系统
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摘要
PURPOSE: A method for controlling target-specificity of a drug delivery system containing a hyaluronic acid derivative is provided to control carboxyl group substitution rate. CONSTITUTION: A target specificity of a drug delivery system containing hyaluronic acid derivatives is controlled by regulating carboxyl group substitution rate of hyaluronic acid derivatives. A target receptor of the drug delivery system is CD44, LYVE-1, RHAMM, or HARE. The drug delivery system contains hyaluronic acid derivatives in which 5 mole%-45mole% of substituted carboxyl group. The drug delivery system contains encapsulated or sealed drug for preventing or treating liver diseases.
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