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A process for the preparation of chirally pure n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine and crystalline modifications thereof

机译：手性纯正-（反式-4-异丙基环己基羰基）-d-苯丙氨酸的制备方法及其结晶修饰

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摘要

The present invention relates to a process for the preparation of crystalline modification "H" of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalaninc (nateglinide) of the formula (I)characterized in that another crystalline modification of the compound having a lower melting point or a mixture of such modifications is boiled in an alkane, preferably in n-hexane or n-heptane, for a short time to provide the product in the stable "H" crystalline form.

机译：本发明涉及制备式（I）的N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸（那格列奈）的结晶变体“ H”的方法 <图像文件=“ IMGA0001.GIF” he =“ 57” id =“ ia01” imgContent =“ chem” imgFormat =“ GIF” wi =“ 66” /> 表征为将具有较低熔点的化合物的另一种结晶变体或这种变体的混合物在烷烃中沸腾，优选在正己烷或正庚烷中短时间煮沸，以提供产物。稳定的“ H”晶型。 展开▼

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公开/公告号EP2264001A1

专利类型

公开/公告日2010-12-22

原文格式PDF

申请/专利权人 RICHTER GEDEON NYRT;
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申请/专利号EP20100181014

发明设计人 HEGEDÛS BÉLA;GIZUR TIBOR;SZEMZÔ ATTILA;TÁRKÁNYI GÁBOR;GAZDAG MÁRIA;BABJÁK MÓNIKA;TÖRLEY JÓZSEF;
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申请日2004-07-08

分类号C07C231/12;C07C231/24;C07C233/63;

国家 EP

入库时间 2022-08-21 17:56:17

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1. N－(反式－4－异丙基环己基羰基)－D－苯丙氨酸的晶形 [P] . 中国专利： CN1304366C . 2007.03.14

2. N－(反式－4－异丙基环己基羰基)－D－苯丙氨酸的晶形 [P] . 中国专利： CN1646481A . 2005-07-27

3. A process for the preparation of chirally pure N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine [P] . 欧洲知识产权局专利： EP2264002A1 . 2010-12-22

机译：制备手性纯的N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸的方法

4. A PROCESS FOR THE PREPARATION OF CHIRALLY PURE N-(TRANS-4-ISOPROPYL-CYCLOHEXYLCARBONIL)-D-PHENYLALANINE AND CRYSTALLINE MODIFICATIONS THEREOF [P] . RS20050980A . 2008-04-04

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5. A PROCESS FOR THE PREPARATION OF CHIRALLY PURE N-(TRANS-4-ISOPROPYL-CYCLOHEXYLCARBONYL)-D-PHENYLALANINE AND CRYSTALLINE MODIFICATIONS THEREOF [P] . EA008883B1 . 2007-08-31

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