首页> 外国专利> POLYETHYLENE GLYCOL-POLY(LACTIC-CO-GLYCOLIC ACID)-POLY(L-LYSINE), PREPARATION METHOD AND USE AS DRUG/GENE CARRIER THEREOF

POLYETHYLENE GLYCOL-POLY(LACTIC-CO-GLYCOLIC ACID)-POLY(L-LYSINE), PREPARATION METHOD AND USE AS DRUG/GENE CARRIER THEREOF

机译：聚乙烯醇-聚（乳酸-乙醇酸）-聚（L-赖氨酸），制备方法及用作药物/基因载体

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摘要

Polyethylene glycol-poly(lactic-co-glycolic acid)-poly(L-lysine) copolymer, its preparation method and use as drug/gene carrier are disclosed. Said copolymer has a molecular weight of 1.0×10³-9.0×10⁸ Dalton, wherein the molar ratio of polyethylene glycol/ poly(lactic-co-glycolic acid) is 1-50: 100-1; the molar ratio of lactide/glycolide(LA/GA) in poly(lactic-co-glycolic acid) is 1-100: 100-1; the molar ratio of polyethylene glycol-poly(lactic-co-glycolic acid)/ poly(L-lysine) is 1-50: 100-1; the molar ratio of polyethylene glycol/poly(lactic-co-glycolic acid)/poly(L-lysine) is 0.1-30: 0.1-80: 1-100.

机译：公开了聚乙二醇-聚（乳酸-乙醇酸共聚物）-聚（L-赖氨酸）共聚物，其制备方法和用作药物/基因载体。所述共聚物的分子量为1.0×10 ^{3 -9.0×10 ^{8 道尔顿，其中聚乙二醇/聚（乳酸-共-乙醇酸）的摩尔比为1-50：100-1;丙交酯-乙醇酸共聚物中丙交酯/乙交酯（LA / GA）的摩尔比为1-100：100-1。聚乙二醇-聚（乳酸-乙醇酸共聚物）/聚（L-赖氨酸）的摩尔比为1-50：100-1。聚乙二醇/聚（乳酸-共-乙醇酸）/聚（L-赖氨酸）的摩尔比为0.1-30：0.1-80：1-100。}}

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公开/公告号WO2011079520A1

专利类型
公开/公告日2011-07-07

原文格式PDF
申请/专利权人 SHANGHAI CANCER INSTITUTE;WANG BINGWU;LI XIAOYU;TAN LIUBIN;QI XUELIAN;CHEN XIAOYAN;DUAN YOURONG;SUN YING;LIU PEIFENG;ZHU MINGJIE;LIANG XIAOFEI;YU HUI;SUN YANMING;WANG QI;
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申请/专利号WO2010CN02180
发明设计人 DUAN YOURONG;SUN YING;LIU PEIFENG;ZHU MINGJIE;LIANG XIAOFEI;YU HUI;SUN YANMING;WANG QI;WANG BINGWU;LI XIAOYU;TAN LIUBIN;QI XUELIAN;CHEN XIAOYAN;
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申请日2010-12-28
分类号C08G63/664;A61K47/34;A61K48;
国家 WO
入库时间 2022-08-21 17:56:54

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