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MICRO-RNA-101 PROMOTES ESTROGEN-INDEPENDENT GROWTH AND CONFERS TAMOXIFEN RESISTANCE IN ER-POSITIVE CANCER CELLS
MICRO-RNA-101 PROMOTES ESTROGEN-INDEPENDENT GROWTH AND CONFERS TAMOXIFEN RESISTANCE IN ER-POSITIVE CANCER CELLS
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机译：MICRO-RNA-101促进雌激素非依赖性生长并赋予正性癌细胞中的他莫昔芬抗性
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摘要
In one aspect, the present invention contemplates a method for assaying estrogen receptor-positive cancer cells for resistance to tamoxifen therapy that comprises assaying those cancer cells for over-production of miR-101. Another aspect contemplates a method of inhibiting the phosphorylation of PTEN in estrogen receptor-positive cancer cells that comprises inhibiting the activity of miR-101. A further aspect of the invention contemplates a method of inhibiting the phosphorylation of Akt in estrogen receptor-positive cancer cells that comprises inhibiting the activity of miR-101. A still further aspect of the invention contemplates a method of increasing the sensitivity of tamoxifen-resistant estrogen receptor- positive cancer cells to tamoxifen that comprises transfecting those cells with antisense miR- 101. Pharmaceutical compositions comprising antisense miR-101 molecules are also provided.
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