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首页> 外国专利> TM7SF3 COMPOSITION FOR DIAGNOSING LIVER CANCER, DIAGNOSTIC KIT CONTAINING ANTI-TM7SF3 ANTIBODIES, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING LIVER CANCER

TM7SF3 COMPOSITION FOR DIAGNOSING LIVER CANCER, DIAGNOSTIC KIT CONTAINING ANTI-TM7SF3 ANTIBODIES, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING LIVER CANCER

机译：用于诊断肝癌的TM7SF3组合物，包含抗TM7SF3抗体的诊断工具包以及用于预防或治疗肝癌的药物组合物

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The present invention relates to a composition for diagnosing liver cancer containing TM7SF3 as an active ingredient, a kit for diagnosing liver cancer with anti-TM7SF3 antibodies as reagent, and a pharmaceutical composition for preventing or treating liver cancer containing the anti-TM7SF3 antibodies as an active ingredient. The TM7SF3 protein is rarely expressed in liver tissue of a healthy person, but is specifically over-expressed in malignant hepatic tissue of liver cancer patients. As diagnosis or prognosis of liver cancer is thus predictable, the TM7SF protein can be used as a marker for diagnosing liver cancer. In addition, the anti-TM7SE3 antibodies of the present invention specifically bind with an extracellular domain of the TTM7SF3, and respond to this particular liver cell line. Therefore, the anti-TM7SE3 antibodies selectively induce apoptosis of only cancer cells caused by IM7SF3 over-expression, and can thus be used in preventing or treating liver cancer.
机译：本发明涉及以TM7SF3为有效成分的肝癌诊断用组合物，以抗TM7SF3抗体为试剂的肝癌诊断用试剂盒，以抗TM7SF3抗体作为抗肝癌的预防或治疗肝癌的药物组合物。有效成分。 TM7SF3蛋白在健康人的肝组织中很少表达，但在肝癌患者的恶性肝组织中特别过表达。由于因此可以预测肝癌的诊断或预后，因此TM7SF蛋白可用作诊断肝癌的标志物。另外，本发明的抗TM7SE3抗体与TTM7SF3的细胞外结构域特异性结合，并对这种特定的肝细胞系产生反应。因此，抗TM7SE3抗体仅选择性地诱导由IM7SF3过表达引起的癌细胞的凋亡，因此可以用于预防或治疗肝癌。

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