首页> 外国专利> ANDROGEN RECEPTOR SUPPRESSORS IN THE THERAPY AND DIAGNOSIS OF PROSTATE CANCER, ALOPECIA AND OTHER HYPER-ANDROGENIC SYNDROMES

ANDROGEN RECEPTOR SUPPRESSORS IN THE THERAPY AND DIAGNOSIS OF PROSTATE CANCER, ALOPECIA AND OTHER HYPER-ANDROGENIC SYNDROMES

机译:前列腺癌,恶性肿瘤和其他高雄激素综合症的治疗和诊断中的雄激素受体抑制剂

摘要

Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamidoand haloarylamino derivatives thereof, as well as radiolabeled derivativesthereof. The compounds bind specifically to the androgen receptor and find usein indications associated with the androgen receptor, such as cell hyperplasiadependent on androgens, hirsutism, acne and androgenetic alopecia.
机译:提供了包含乙内酰脲,尿素或2-的取代的苯丙氨酸。羟基,2-甲基丙酰基,其二聚体和烷基,多氟酰胺基及其卤代芳基氨基衍生物,以及放射性标记的衍生物其。这些化合物与雄激素受体特异性结合并找到用途与雄激素受体有关的适应症,例如细胞增生依赖雄激素,多毛症,痤疮和雄激素性脱发。

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