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A hybrid adenovirus-alphavirus vector for efficient delivery and expression of therapeutic genes in tumor cells.
A hybrid adenovirus-alphavirus vector for efficient delivery and expression of therapeutic genes in tumor cells.
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机译：用于在肿瘤细胞中有效传递和表达治疗基因的杂交腺病毒-α病毒载体。
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摘要
The present invention relates to a hybrid adenoviral gene expression vector comprising, oriented 5 '' to 3 '', at least the following elements: i. a first chain of adenoviral origin comprising a first inverted terminal repeat sequence (ITR) and a signal sequence for packaging of the adenovirus; ii. a first filler noncoding sequence; iii. corresponding to a tissue specific promoter sequence; iv. a chain of cDNA derived from an alphavirus, the sequence of which is partly complementary to an alphaviral RNA, comprising at least a sequence encoding at least one exogenous gene of interest v. a polyadenylation sequence and vi. a second inverted terminal repeat sequence (ITR) adenoviral; preferably it relates to an adenoviral hybrid vector comprising as exogenous gene of interest the therapeutic gene of mammalian interleukin IL-12, and even more preferably human interleukin hIL-12; and the use of the hybrid vector in a process for transferring genetic material to a cell, especially a tumor cell and preferably expressing AFP, and their use to induce an immune response against foreign antigens.
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