首页> 外国专利> METHOD FOR EVALUATION OF PECULIARITIES OF AFFECTION OF ENDOTHELIUM AND MANIFESTATIONS OF PATHOLOGICAL CHANGES IN VESSELS AT ACUTE CORONARY SYNDROME

METHOD FOR EVALUATION OF PECULIARITIES OF AFFECTION OF ENDOTHELIUM AND MANIFESTATIONS OF PATHOLOGICAL CHANGES IN VESSELS AT ACUTE CORONARY SYNDROME

机译:急性冠状动脉综合征患者血管内皮功能影响评估和病理改变的评估方法

摘要

Method for evaluation of peculiarities of affection of endothelium and manifestations of pathological changes in vessels at acute coronary syndrome includes blood sampling in patients, separation and calculation under microscope as criterion of structural damage of endothelium of circulating desquamated endothelial cells in plasma enriched with thrombocytes. Additionally as criterion for evaluation one determines on blood serum concentration of dissolved cardegin of endothelium of vessels (VE-cardegin) with joint evaluation of criteria of structural damage of endothelium and if compared to set norm number of circulating desquamated endothelial cells in 10 ml of plasma saturated with thrombocytes and concentration of VE-cardegin in blood serum are increased not less that 2 times one makes conclusion on damage of continuousness of endothelium and presence of pathological changes in coronary vessels that are expressed in distortion of intercellular adhesion of vascular endothelium , these are interrelated and amplifying factors of risk of development of cardiovascular events at acute coronary syndromes.
机译:评价急性冠状动脉综合征的内皮功能的特殊性和血管的病理变化的方法包括:对患者进行血液采样,在显微镜下分离和计算,作为富含血小板的血浆中循环脱水内皮细胞的内皮结构损伤的标准。另外,作为评估的标准,通过联合评估内皮的结构损伤的标准,以及与设定的10 ml血浆中循环的脱皮内皮细胞的标准数量进行比较,可以确定血管内皮溶解的心蛋白(VE-cardegin)的血清浓度至少有2倍增加了血小板饱和和血清中VE-心铁蛋白的浓度,得出了内皮连续性受损和冠状血管存在病理变化的结论,这些变化以血管内皮细胞间粘附的畸变表达,这些是急性冠脉综合征发生心血管事件的风险的相互关联和放大因素。

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