首页> 外国专利> Variant of mother polypeptide containing Fc region, polypeptide containing variant of Fc region with altered affinity of Fc gamma receptor binding (Fc R), polypeptide containing variant of Fc region with altered affinity of Fc gamma neonatal receptor binding (Fc Rn), composition, isolated nucleic acid, vector, host cell, method for obtaining polypeptide variant, the use thereof and method for obtaining region Fc variant

Variant of mother polypeptide containing Fc region, polypeptide containing variant of Fc region with altered affinity of Fc gamma receptor binding (Fc R), polypeptide containing variant of Fc region with altered affinity of Fc gamma neonatal receptor binding (Fc Rn), composition, isolated nucleic acid, vector, host cell, method for obtaining polypeptide variant, the use thereof and method for obtaining region Fc variant

机译：包含Fc区的母体多肽的变体，具有Fcγ受体结合（Fc R）亲和力改变的Fc区变体的多肽，具有Fcγ新生受体结合（Fc Rn）亲和力改变的Fc区的多肽，组成核酸，载体，宿主细胞，获得多肽变体的方法，其用途和获得区域Fc变体的方法

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摘要

A polypeptide comprising a variant Fc region, which polypeptide comprises an amino acid modification at any one or more of amino acid positions 256, 290, 298, 312, 326, 330, 333, 360, 378 or 430 of the Fc region.

机译：包含变体Fc区的多肽，该多肽在Fc区的256、290、298、312、326、330、333、360、378或430位氨基酸中的任何一个或多个处包含氨基酸修饰。

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公开/公告号PL209786B1

专利类型
公开/公告日2011-10-31

原文格式PDF
申请/专利权人 GENENTECH INC.;
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申请/专利号PL20000388183
发明设计人 PRESTA LEONARD G.;
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申请日2000-01-14
分类号C07K16/28;G01N33/53;A61K38;A61P11/06;A61P35;A61P37/08;A61P43;C07K16;C07K16/18;C07K16/22;C07K16/42;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/13;C12P21/02;G01N33/566;
国家 PL
入库时间 2022-08-21 18:04:56

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