首页> 外国专利> ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR COMPRISING A SUGAR CHAIN AT ASPARAGINE 297 WITH BETWEEN 20 TO 50 FUCOSE

ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR COMPRISING A SUGAR CHAIN AT ASPARAGINE 297 WITH BETWEEN 20 TO 50 FUCOSE

机译:我所接受的抗胰岛素样生长因子的抗体包括糖精在297型糖精中的糖链含量在20%至50%之间

摘要

Disclosed is an antibody binding to IGF-IR and being glycosylated with a sugar chain at amino acid asparagine located at position 297 in the Fc region, said antibody being characterized in that the amount of fucose within said sugar chain is between 20% and 50%. Further disclosed are pharmaceutical composition comprising said antibody and uses there in the manufacture of a medicament for the treatment of cancer.
机译:公开了一种与IGF-1R结合并被位于Fc区297位的氨基酸天冬酰胺上的糖链糖基化的抗体,所述抗体的特征在于所述糖链内的岩藻糖量在20%至50%之间。还公开了包含所述抗体的药物组合物,并在其中用于制备用于治疗癌症的药物。

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