首页> 外国专利> METHOD FOR THE DIFFERENTIATION OF HUMAN ADULT STEM CELLS INTO INSULIN-SECRETING CELLS.

METHOD FOR THE DIFFERENTIATION OF HUMAN ADULT STEM CELLS INTO INSULIN-SECRETING CELLS.

机译:将人类成年干细胞分化为分泌胰岛素的细胞的方法。

摘要

Disclosed is a method for differentiating human adult stem cells into insulin-secreting cells. Human adult stem cells, isolated from the subcutaneous adipose tissues around the eyes, are induced to differentiate into insulin-secreting cells in a medium in the presence of cytokines and growth factors including B27 supplement, fibroblast growth factor-2, epidermal growth factor, nicotinamide, glucagon-like peptide-1, activin A, insulin-like growth factor, betacellulin, etc., with a glucose shift from a high concentration to a low concentration. Having the ability to producing insulin and C-peptide at high levels, the insulin-secreting cells can be excellent curatives for type 1 diabetes mellitus.
机译:公开了一种将人成年干细胞分化为分泌胰岛素的细胞的方法。在存在细胞因子和生长因子(包括B27补充剂,成纤维细胞生长因子-2,表皮生长因子,烟酰胺)的细胞因子存在下,从眼睛周围的皮下脂肪组织中分离出的人类成年干细胞被诱导分化为分泌胰岛素的细胞。 ,例如胰高血糖素样肽-1,激活素A,胰岛素样生长因子,β纤维素等,其葡萄糖从高浓度转变为低浓度。分泌胰岛素的细胞具有产生高水平胰岛素和C肽的能力,可以作为1型糖尿病的优良治疗剂。

著录项

  • 公开/公告号MX2010004284A

    专利类型

  • 公开/公告日2011-10-26

    原文格式PDF

  • 申请/专利权人 CJ CHEILJEDANG CORPORATION;

    申请/专利号MX20100004284

  • 发明设计人 HAE KWON KIM;HYUN MI KANG;

    申请日2010-04-19

  • 分类号C12N5/00;

  • 国家 MX

  • 入库时间 2022-08-21 18:05:27

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