首页> 外国专利> METHODS FOR GENERATING A NON-HUMAN VERTEBRATE ANIMAL MODEL HAVING TARGET NORMAL TISSUE OF MATURE PHENOTYPE AND TARGET DISEASED TISSUES FROM A DONOR VERTEBRATE ANIMAL, TISSUE MODELS AND IMMUNODEFICIENT RODENTS PRODUCED THEREOF, AND METHODS FOR ASSESSING THE EFFECT OF A THERAPEUTIC TREATMENT DIRECTED AGAINST A TARGET DISEASED TISSUE

METHODS FOR GENERATING A NON-HUMAN VERTEBRATE ANIMAL MODEL HAVING TARGET NORMAL TISSUE OF MATURE PHENOTYPE AND TARGET DISEASED TISSUES FROM A DONOR VERTEBRATE ANIMAL, TISSUE MODELS AND IMMUNODEFICIENT RODENTS PRODUCED THEREOF, AND METHODS FOR ASSESSING THE EFFECT OF A THERAPEUTIC TREATMENT DIRECTED AGAINST A TARGET DISEASED TISSUE

机译：产生具有正常表型和目标疾病组织的非人类无脊椎动物动物模型的方法，该模型是根据动物的无脊椎动物动物，组织模型和所产生的不全缺陷而进行的，其方法是为此目的而进行的，其治疗方法是：组织

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摘要

The invention relates to the use of fetal tissues to generate a tissue model in a non-human animal. The tissue model comprises target tissues allowed to progress through development in vivo in a non-human host in order to obtain tissues having a mature phenotype that can be sued to assess toxicity and/or efficacy of an agent.

机译：本发明涉及胎儿组织在非人类动物中产生组织模型的用途。组织模型包括被允许在非人宿主中通过体内发育而进展的靶组织，以便获得具有成熟表型的组织，可将其用于评估试剂的毒性和/或功效。

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公开/公告号IL165128B

专利类型
公开/公告日2010-12-30

原文格式PDF
申请/专利权人 MACROGENICS WEST INC.;
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申请/专利号IL165128
发明设计人
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申请日2004-11-09
分类号A01K67/027;A01K;A01K33;A61K35;A61K35/12;A61K49;C12N5/06;G01N33/15;
国家 IL
入库时间 2022-08-21 18:06:26

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