首页> 外国专利> Methods for selecting at least one molecule, for producing a composition, for enhancing extracellular protein degradation and / or elimination of protein in an individual, for inhibiting at least in part, misfolded protein and / or crossborder mediated effects for at least partial prevention and / or treatment of a disease, disorder and / or infection, to partially remove misfolded proteins, cross-linked structures and / or proteins to determine if a malfunctioning protein protein, and / or a protein and / or peptide comprising a cross-structure is present in an aqueous solution, to reduce and / or prevent undesirable side effects of a pharmaceutical composition and / or to increase protein gram specific activity, to interfere with blood clotting to determine the amount of misfolded proteins and / or cross-structures in a composition to determine a difference cross-frame structure, to determine the identity of a misfolded protein, cross-frame or protein, and to treat a subject sufferin

Methods for selecting at least one molecule, for producing a composition, for enhancing extracellular protein degradation and / or elimination of protein in an individual, for inhibiting at least in part, misfolded protein and / or crossborder mediated effects for at least partial prevention and / or treatment of a disease, disorder and / or infection, to partially remove misfolded proteins, cross-linked structures and / or proteins to determine if a malfunctioning protein protein, and / or a protein and / or peptide comprising a cross-structure is present in an aqueous solution, to reduce and / or prevent undesirable side effects of a pharmaceutical composition and / or to increase protein gram specific activity, to interfere with blood clotting to determine the amount of misfolded proteins and / or cross-structures in a composition to determine a difference cross-frame structure, to determine the identity of a misfolded protein, cross-frame or protein, and to treat a subject sufferin

机译：选择至少一个分子，制备组合物，增强个体中细胞外蛋白质降解和/或消除蛋白质，至少部分抑制蛋白质错误折叠和/或跨界介导的作用以至少部分预防和/的方法或治疗疾病，病症和/或感染，以部分除去错误折叠的蛋白质，交联结构和/或蛋白质，以确定是否存在功能异常的蛋白质和/或包含交叉结构的蛋白质和/或肽在水溶液中，以减少和/或预防药物组合物的不良副作用和/或增加蛋白质克的比活性，干扰血液凝结以确定组合物中错折叠的蛋白质和/或交叉结构的数量，确定不同的跨框架结构，确定错误折叠的蛋白质，跨框架或蛋白质的身份，并治疗受试者

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METHODS TO SELECT AT LEAST ONE MOLECULE, TO PRODUCE A COMPOSITION, TO INCREASE EXTRACELLULAR PROTEIN DEGRADATION AND / OR PROTEIN ELIMINATION IN AN INDIVIDUAL, TO INHIBIT, AT LEAST IN PART, EARNED MEASURES AND / OR MULTI-PROTEIN OR PROTEIN. , FOR PREVENTION AT LEAST PARTIAL AND / OR TREATMENT OF A DISEASE, DISTURBANCE AND / OR INFECTION, TO REMOVE, AT LEAST PARTIALLY, MALFOLDED PROTEINS, B CROSS STRUCTURES AND / OR PROTEINS, TO DETERMINE IF A PROTEIN -FOLDING, AND / OR A PROTEIN AND / OR PEPTIDE UNDERSTANDING A CROSS-STRUCTURE B IS PRESENT IN A WATER SOLUTION, TO REDUCE AND / OR PREVENT UNWANTED SIDE EFFECTS OF A PHARMACEUTICAL AND / OR INCREASING PROTEIN OF PHARMACEUTICAL ACTIVITY, INGREDIATING THE ACTIVITY OF GRADE. INTERFER IN BLOOD COAGULATION, TO DETERMINE THE AMOUNT OF MAL-FOLDED PROTEINS AND / OR CROSS-STRUCTURES B IN A COMPOSITION, TO DETERMINE A DIFFERENCE IN THE STRENGTH CONTENT UTURA B CROSSED, TO DETERMINE THE IDENTITY OF A BAD-FOLDED PROTEIN, A CROSS-STRUCTURE B OR A PROTEIN, AND TO TREAT A SUBJECT SUFFERING FROM, OR AT RISK OF, DISEASE, DISTURB AND / OR ONE INFECTION, COLLECTION OF MOLECULES OF IGIV, COMPOSITION, USE OF A COLLECTION OF MOLECULES OF IGIV AND / OR OF A COMPOSITION, DIAGNOSTIC KIT, SEPARATION DEVICE, COMPOUND, AND, USE OF A COMPOUND to select the least method for the present invention provides a method for selecting this method. an IgJV molecule, from a collection of IgJV molecules comprising an affinity region that is capable of interacting with an incorrectly folded protein and / or with an epitope of a crossed structure and / or with an epitope of a protein comprising a structure 13 crossed, wherein said method comprises contacting a collection of IgIV molecules with a misfolded protein and / or with a crossed structure and / or with a protein comprising a structure ra 13 cross, and collect at least one IgJV molecule comprising an affinity region interacting with said epitope and / or incorrectly folded protein.

机译：至少选择一种分子，生产一种成分，增加单个细胞外蛋白质降解和/或蛋白质消除的方法，至少部分地抑制获得的措施和/或多蛋白质或蛋白质。为了至少部分地预防和/或治疗疾病，干扰和/或感染，以至少部分地去除马尔代夫的蛋白质，交叉结构和/或蛋白质，以便确定是否存在蛋白质折叠和/或蛋白质和/或肽类具有跨结构B的含义，存在于水溶液中，以减少和/或防止药物的不良作用和/或增加药物活性的蛋白质，从而提高蛋白质的活性。干扰血液凝结，以确定组合物中恶意折叠的蛋白质和/或交叉结构B的量，确定交叉的强度成分UTURA B的差异，确定交叉折叠的蛋白质的身份， -结构B或蛋白质，并处理遭受，处于感染，干扰或/和一次感染，感染IGIV分子，组成，使用IGIV和/或A的分子的疾病组合物，诊断试剂盒，分离装置，化合物以及使用化合物选择本发明的最少方法提供了一种选择该方法的方法。 IgJV分子，其来自包含亲和区的IgJV分子，该亲和区能够与不正确折叠的蛋白质和/或与交叉结构的表位和/或与包含交叉的13结构的蛋白的表位相互作用，其中所述方法包括使一组IgIV分子与错误折叠的蛋白质和/或具有交叉结构的蛋白质和/或与具有ra 13交叉结构的蛋白质接触，并收集至少一个包含与所述表位和/或相互作用的亲和力区域的IgJV分子。或蛋白质折叠错误。

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公开/公告号BRPI0707848A2

专利类型
公开/公告日2011-05-10

原文格式PDF
申请/专利权人 CROSSEBETA BIOSCIENCES B.V.;
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申请/专利号BR2007PI07848
发明设计人 MARTIJN FRANS BEN GERARD GERBINK;BAREND BOUMA;
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申请日2007-02-16
分类号C07K16/18;A61K39/395;A61P25/28;C07K1/22;G01N33/68;
国家 BR
入库时间 2022-08-21 18:07:09

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