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thraustochytrid delta-6 desaturase and its uses
thraustochytrid delta-6 desaturase and its uses
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机译:破囊壶菌δ6去饱和酶及其用途
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摘要
DELTA-6 THRAUSTOCHYTRID DESATURASE AND ITS USES. The present invention relates to a Delta-6 desaturase gene isolated from Schizochytríum. it is also directed to the cloning of Delta-6 desaturase derived from Schizochytrium in Yeast. The sequence of nucleic acids and the amino acid sequences of Delta-6 desaturase are described. Also described are the constructs, a vector comprising the gene encoding the Delta-6 desaturase enzyme in functional combination with the heterologous regulatory sequences. The new Delta-6 desaturase can be used in a metabolic pathway to convert linoleic acid to gamma linolenic acid (omega-6 pathway). The invention provides for the identification, isolation of these new Schizochytrium nucleic acids that encode the proteins mentioned above. The invention specifically exemplifies recombinant yeast cells harboring the vector comprising the Delta-6 desaturase gene and by virtue of the enzyme produced it may be able to produce gamma linolenic acid.
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