首页> 外国专利> isolated human monoclonal antibody, composition, immunoconjugate, bispecific molecule, isolated nucleic acid molecule, expression vector, host cell, transgenic mouse, method for modulating an immune response in an individual, method for inhibiting tumor cell growth in an individual, method for treating an infectious disease in a subject, a method for enhancing an immune response to an antigen in a subject, a method for treating or preventing an inflammatory disease in a subject, and a method for preparing the anti-pd-11 antibody

isolated human monoclonal antibody, composition, immunoconjugate, bispecific molecule, isolated nucleic acid molecule, expression vector, host cell, transgenic mouse, method for modulating an immune response in an individual, method for inhibiting tumor cell growth in an individual, method for treating an infectious disease in a subject, a method for enhancing an immune response to an antigen in a subject, a method for treating or preventing an inflammatory disease in a subject, and a method for preparing the anti-pd-11 antibody

机译：分离的人单克隆抗体，组合物，免疫缀合物，双特异性分子，分离的核酸分子，表达载体，宿主细胞，转基因小鼠，在个体中调节免疫应答的方法，在个体中抑制肿瘤细胞生长的方法，治疗方法受试者的传染病，增强受试者对抗原的免疫反应的方法，治疗或预防受试者的炎性疾病的方法以及制备抗pd-11抗体的方法

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MONOCLONAL HUMAN ISOLATED, COMPOSITION, immunoconjugate molecule bispecific molecule Nucleic Acid ISOLATED, expression vector, host cell, MOUSE TRANSCêNICO, METHOD FOR MODULAR AN IMMUNE an individual ANSWER, method for inhibiting cell growth TUMOR an individual, METHOD TO TREAT "INFECTIOUS DISEASE IN AN INDIVIDUAL, METHOD FOR INCREASING AN IMMUNE RESPONSE TO AN ANTIQUE, METHOD FOR TREATING OR PREVENTING AN INFLAMMATORY DISEASE, AND METHOD FOR PREPARING ANTI-ANTIPLE, Isolated human monoclonal antibodies that specifically bind to high affinity PD-L1 Nucleic acid molecules encoding the antibodies of the present disclosure, expression vectors, host cells and methods for expressing the antibodies of the present disclosure are also provided. bispecific and with Pharmaceutical positions comprising the antibodies of the invention are also provided. The description also provides methods for detecting PD-L1 as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-L1 antibodies.

机译：完整的人类隔离，组成，免疫共轭物分子双特异性分子，核酸分离，表达载体，宿主细胞，MOUSETRANSCêNICO，对单个人免疫的模块式方法，抑制个体肿瘤生长的方法，在个体中治疗“传染病”的方法，增加对古董的免疫反应的方法，治疗或预防炎症的方法以及制备抗抗体的方法，分离的人单克隆抗体可以与编码本发明抗体的高亲和力PD-L1核酸分子特异性结合公开内容，还提供了表达本公开内容的抗体的表达载体，宿主细胞和方法，还提供了双特异性的并且具有包含本发明抗体的药物位置的描述，该说明书还提供了检测PD-L1的方法以及方法用于治疗各种疾病，包括癌症和传染病使用抗PD-L1抗体。

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公开/公告号BRPI0613361A2

专利类型
公开/公告日2011-01-04

原文格式PDF
申请/专利权人 MEDAREX INC.;
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申请/专利号BR2006PI13361
发明设计人 ALAN J. KORMAN;MARK J. SELBY;CHANGYU WANG;MOHAN SRINIVASAN;DAVID B. PASSMORE;HAICHUN HUANG;HAIBIN CHEN;
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申请日2006-06-30
分类号C07K16/28;
国家 BR
入库时间 2022-08-21 18:07:14

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