首页> 外国专利> isolated polypeptide, antibodies or fragments thereof, cell, methods of diagnosis and treatment of acute leukemia, blast crisis chronic leukemia and lymphoblastic lymphoma, pharmaceutical compositions and diagnostic kits

isolated polypeptide, antibodies or fragments thereof, cell, methods of diagnosis and treatment of acute leukemia, blast crisis chronic leukemia and lymphoblastic lymphoma, pharmaceutical compositions and diagnostic kits

机译:分离的多肽,抗体或其片段,细胞,急性白血病,原始危机,慢性白血病和淋巴母细胞淋巴瘤的诊断和治疗方法,药物组合物和诊断试剂盒

摘要

Isolated Polypeptide, Antibodies or Respective Fragments, Cell, Methods of Diagnosis and Treatment of Acute Leukemia, Chronic Crisis Leukemia, and Lymphoblastic Lymphoma, Pharmaceutical Compositions, and Diagnostic Kits The present invention relates to an expressed GD43 epitope in acute human leukemia and lymphoblastic lymphoma cells and their use. More particularly, the present invention relates to a CD43 epitope expressed in acute human leukemia and lymphoblastic lymphoma cells, but not in mature hematopoietic cells and hematopoietic stem cells and non-hematopoietic cells and their diagnostic and therapeutic application on acute leukemia and lymphoblastic lymphoma.
机译:分离的多肽,抗体或相应片段,细胞,急性白血病,慢性危机白血病和淋巴母细胞淋巴瘤的诊断和治疗方法,药物组合物和诊断试剂盒本发明涉及急性人白血病和淋巴母细胞淋巴瘤细胞中表达的GD43表位。及其用途。更具体地,本发明涉及在急性人白血病和淋巴母细胞淋巴瘤细胞中表达但在成熟的造血细胞和造血干细胞和非造血细胞中不表达的CD43表位及其在急性白血病和淋巴母细胞淋巴瘤中的诊断和治疗应用。

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