首页> 外国专利> compound, methods for limiting cell proliferation, treatment of a human or animal suffering from a disease, and treatment of cancer prophylaxis, treatment of cancer, treatment of cancer-associated infections, and prophylaxis of cancer-associated infections. , pharmaceutical composition, use of a compound or a pharmaceutically acceptable salt thereof, methods for inhibiting chk1 kinase, and a pak kinase, and for limiting tumorigenesis in a human or animal, and process for preparing a compound or a pharmaceutically acceptable salt thereof

compound, methods for limiting cell proliferation, treatment of a human or animal suffering from a disease, and treatment of cancer prophylaxis, treatment of cancer, treatment of cancer-associated infections, and prophylaxis of cancer-associated infections. , pharmaceutical composition, use of a compound or a pharmaceutically acceptable salt thereof, methods for inhibiting chk1 kinase, and a pak kinase, and for limiting tumorigenesis in a human or animal, and process for preparing a compound or a pharmaceutically acceptable salt thereof

机译:化合物,限制细胞增殖的方法,患有疾病的人或动物的治疗以及癌症预防的治疗,癌症的治疗,与癌症相关的感染的治疗以及与癌症相关的感染的预防。 ,药物组合物,化合物或其药学上可接受的盐的用途,抑制chk1激酶和pak激酶以及限制人或动物中肿瘤发生的方法,以及制备化合物或其药学上可接受的盐的方法

摘要

COMPOSITION, METHODS TO LIMIT CELL PROLIFERATION, TREATMENT OF A HUMAN OR ANIMAL BEING SUFFERED FROM A DISEASE, AND TREATMENT OF CANCER PROPHILAXY, TO TREAT CANCER, TREATMENT OF INFECTIONS WITH CANCER AND HEALTH-ASSOCIATED CANCER , PHARMACEUTICAL COMPOSITION, USE OF A PHARMACEUTICALLY ACCEPTABLE COMPOUND OR EXIT, METHODS FOR INHIBITING CHK1 KINASE, AND A PAK KINASE, AND TO LIMIT TUMORIGENESIS IN A HUMAN OR ANIMAL BEING, AND A PROCESS FOR PREPARING PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME This invention relates to the novel compounds of Formula (1) and their pharmaceutical compositions and their methods of use. These novel compounds have CHK1 kinase inhibitory activity, PDK1 inhibitory activity and Pak kinase inhibitory activity and are therefore useful in cancer treatment and / or prophylaxis.
机译:组成成分,限制细胞增殖的方法,治疗人类或动物疾病的方法以及癌变的治疗方法,以治疗癌症,治疗癌症和与健康相关的癌症,药物成分,药物成分的用途或退出,用于抑制CHK1激酶和PAK激酶,限制人类或动物体内透血性肿瘤的方法,以及制备该药物的药学可接受的盐的方法本发明涉及式(1)的新型化合物及其化合物药物组合物及其使用方法。这些新型化合物具有CHK1激酶抑制活性,PDK1抑制活性和Pak激酶抑制活性,因此可用于癌症治疗和/或预防。

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