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adenovirus vector, immunogenic composition, use of an adenovirus vector, method for preparing a vector, use of a virus vector and a pharmaceutically acceptable carrier or adjuvant, and fusion protein
adenovirus vector, immunogenic composition, use of an adenovirus vector, method for preparing a vector, use of a virus vector and a pharmaceutically acceptable carrier or adjuvant, and fusion protein
ADENOVIRUS VECTOR, JMUNOGENIC COMPOSITION, USE OF AN ADENUS VIRUS VECTOR, METHOD FOR PREPARING A VECTOR, USE OF A VIRUS VECTOR AND PHARMACEUTICALLY ACCEPTABLE ADJUSTER, AND, FUSION PROTEIN. The present invention relates to virus vectors comprising oligonucleotides encoding HIV polypeptides, more particularly wherein the virus vector is an adenovirus. In particular, such adenoviruses are non-human primate adenoviruses such as simian adenoviruses, more particularly chimpanzee adenoviruses. In particular the invention relates to adenovirus vectors comprising HIV polynucleotide sequences encoding multiple different 111V antigens, for example two or three or more HIV antigens. The invention further relates to methods of preparing virus vectors, virus vectors produced by the methods and the use of the vectors in medicine especially prophylactic or therapeutic vaccination.
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