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Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists

机译:4-溴甲基-2'-甲酰基联苯和4-溴甲基-2'-羟甲基联苯的合成及其在血管紧张素Ⅱ拮抗剂制备中的应用

摘要

4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from 4-bromomethyl-2′-cyanobiphenyl or 4′-bromomethylbiphenylcarboxyilic derivatives using selected hydride reagent.
机译:4-溴甲基-2'-甲酰基联苯和4-溴甲基-2'-羟甲基联苯是制备各种血管紧张素II拮抗剂的有用起始原料,它们是由4-溴甲基-2'-氰基联苯或4'-溴甲基联苯羧化衍生物使用选定的氢化物制备的试剂。

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