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Methods to identify patients at risk of developing adverse events during treatment with antidepressant medication

机译:识别使用抗抑郁药治疗期间有发生不良事件风险的患者的方法

摘要

The invention provides a method of screening patients to identify those patients more likely to exhibit an increased risk of treatment-emergent suicidal ideation comprising: (a) obtaining a sample of genetic material from the patients, and (b) assaying the sample for the presence of a genotype in the patients which is associated with an increased risk of treatment-emergent suicidal ideation, wherein the genotype is characterized by a polymorphism in a gene selected from the group consisting of glutamine receptor, ionotropic, kainate 2 (GRIK2); glutamate receptor ionotropic AMPA 3 (GRIA3); and combinations thereof.
机译:本发明提供了一种筛选患者的方法,以鉴定那些更有可能表现出更高的治疗紧急自杀意念风险的患者,包括:(a)从患者中获得遗传物质的样品,以及(b)分析该样品中是否存在所述患者的基因型与增加的治疗性自杀意念的风险有关,其中所述基因型的特征在于选自谷氨酰胺受体,离子型,红藻氨酸2(GRIK2)的基因中的多态性;谷氨酸受体离子型AMPA 3(GRIA3);及其组合。

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