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Infusion of a Mixture of Autologous Bone Marrow-Derived Mononuclear Cells and Autologous or Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for Treating Myocardial and/or Cardiovascular Disorders
Infusion of a Mixture of Autologous Bone Marrow-Derived Mononuclear Cells and Autologous or Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for Treating Myocardial and/or Cardiovascular Disorders
The present invention is a method for improving cardiac and/or cardiovascular functions in living subjects after the occurrence of a myocardial and/or cardiovascular disorder, involving tissue damage and/or an ischemic event. The method is a combination stem cell therapy involving a mixture of bone marrow-derived mesenchymal stem cells and bone marrow-derived mononuclear cells surgically implanted by using either a direct or catheter-mediated injection into damaged tissue. Studies have shown that the implant improves blood perfusion in an ischemic tissue and thus contributes to the recovery of cardiac and/or cardiovascular function as assessed by methods of choice, including magnetic resonance imaging (“MRI”), echocardiography, angiography and 99mTc-TF perfusion scintigraphy.
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