首页> 外国专利> Use of Additive Sites to Control Nitric Oxide Release from Nitric Oxide Donors Contained within Polymers

Use of Additive Sites to Control Nitric Oxide Release from Nitric Oxide Donors Contained within Polymers

机译:使用加成位点控制聚合物中一氧化氮供体释放一氧化氮

摘要

A method for increasing, prolonging, and/or controlling the release rates of nitric oxide (NO) from polymeric materials containing NO adducts. Such NO-containing polymeric materials may find use in devices such as blood contacting devices, and biocompatible devices utilizing the same. The method and device utilizes anionic site additives, acidic site additives and/or acidic producing site additives in a polymer that contains NO-adducts to generate higher fluxes of NO to exceed NO threshold levels desirable to substantially prevent and/or minimize reactions such as platelet activation or adhesion.
机译:一种用于增加,延长和/或控制一氧化氮(NO)从含有NO加合物的聚合材料中释放速率的方法。此类含NO的聚合材料可用于装置中,例如血液接触装置和利用该材料的生物相容性装置。该方法和装置在包含NO-加合物的聚合物中利用阴离子位点添加剂,酸性位点添加剂和/或酸性产生位点添加剂来产生更高的NO通量,以超过实质上防止和/或最小化反应所需的NO阈值水平。激活或粘附。

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