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Use of Additive Sites to Control Nitric Oxide Release from Nitric Oxide Donors Contained within Polymers
Use of Additive Sites to Control Nitric Oxide Release from Nitric Oxide Donors Contained within Polymers
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机译:使用加成位点控制聚合物中一氧化氮供体释放一氧化氮
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摘要
A method for increasing, prolonging, and/or controlling the release rates of nitric oxide (NO) from polymeric materials containing NO adducts. Such NO-containing polymeric materials may find use in devices such as blood contacting devices, and biocompatible devices utilizing the same. The method and device utilizes anionic site additives, acidic site additives and/or acidic producing site additives in a polymer that contains NO-adducts to generate higher fluxes of NO to exceed NO threshold levels desirable to substantially prevent and/or minimize reactions such as platelet activation or adhesion.
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