Method for detecting vulnerable plaque using a quantitative colorimetric analysis while performing the angioscopy

• 1. 基于注意力模型及多任务神经网络的心血管易损斑块识别方法及系统 [P] . 中国专利： CN108492272B . 2021.01.19
• 2. 心血管光学相干断层OCT图像易损斑块自动识别方法 [P] . 中国专利： CN107993221B . 2021.11.02
• 3. Methods for detection of vulnerable plaque with quantitative colorimetry during angioscopy [P] . 美国专利： US8774905B2 . 2014-07-08

  机译： 血管镜检查中定量比色法检测易损斑块的方法

• 4. METHODS FOR DETECTION OF VULNERABLE PLAQUE WITH QUANTITATIVE COLORIMETRY DURING ANGIOSCOPY [P] . 世界知识产权组织专利： WO2009032206A1 . 2009-03-12

  机译： 血管造影定量比色法检测牙菌斑的方法。

• 5. Quantitative imaging for detecting vulnerable plaque [P] . US11113812B2 . 2021-09-07

  机译： 检测脆弱斑块的定量成像

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• 1. 18F-FDG PET/CT for Detecting Vulnerable Carotid Plaque:A Systematic Review of Literatures [J] . Ping Zhou1 ,Weijie Xie1 ,Ping Zheng2 . TMR临床研究 . 2019,第001期
• 2. Analysis of Urea in Petfood Matrices: Comparison of Spectro-Colorimetric, Enzymatic and Liquid Chromatography Electrospray Ionization High Resolution Mass Spectrometry Methods [J] . Patrick Pibarot ,Serge Pilard . 美国分析化学（英文） . 2012,第9期
• 3. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 4. A Method for Vulnerability Database Quantitative Evaluation [J] . Tiantian Tan ,Baosheng Wang ,Yong Tang . 计算机、材料和连续体(英文) . 2019,第9期
• 5. 动脉粥样硬化易损斑块与斑块内血管新生的关系探讨 [C] . 许敏华 ,贾钰华 . 第八届国际中西医结合学术交流大会暨心血管病学术论坛 . 2016
• 6. 急性冠状动脉综合征易损斑块和血管重构的血管内超声研究 [A] . 任国瑞 . 2006