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The cell bioassay tip/chip which uses the myocardial heartbeat cell and the bioassay null substrate which uses

机译:使用心肌心跳细胞的细胞生物测定法尖端/芯片和使用心肌细胞的生物测定法无效底物

摘要

PROBLEM TO BE SOLVED: To enable a myocardial cell bioassay having a myocardial pulsating cell network in a state of physical contact with other cell/interaction between cells.;SOLUTION: In a cell bioassay chip, a collected cell microarray having grooves or tunnels connecting spaces between a plurality of partition walls for adjacently trapping four or more myocardial pulsating cells in specific space configurations and providing a plurality of electrode patterns for measuring electric potential change of cells in each groove or tunnel and arranging optically transparent semipermeable membranes and culture solution tanks on the partition walls is formed on a substrate one myocardial pulsating cell is stored each of a plurality of micropartitions and a test sample is added to each of micropartitions and electric potential change or shape change of cells stored in each of the micropartitions is observed to carry out bioassay.;COPYRIGHT: (C)2006,JPO&NCIPI
机译:解决的问题:使具有心肌搏动细胞网络的心肌细胞生物测定处于与其他细胞物理接触/细胞间相互作用的状态;解决方案:在细胞生物测定芯片中,收集的细胞微阵列具有连接空间的沟槽或隧道在多个间隔壁之间,用于在特定的空间配置中相邻捕获四个或更多的心肌搏动细胞,并提供多个电极图案,用于测量每个凹槽或隧道中细胞的电势变化,并在其上布置光学透明的半透膜和培养液槽在基板上形成分隔壁。一个心肌搏动细胞被存储在多个微分区中的每个微分区中,并且将测试样品添加到每个微分区中,并观察存储在每个微分区中的细胞的电势变化或形状变化以进行生物测定。 。;版权:(C)2006,JPO&NCIPI

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