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ANGIOTENSIN I CONVERTING ENZYME INHIBITOR FROM WHEAT BRAN, BARLEY BRAN AND RICE BRAN

机译:血管紧张素I转化为小麦麸,大麦麸和大米麸的酶抑制剂

摘要

PROBLEM TO BE SOLVED: To economically and efficiently provide an active ingredient having angiotensin I converting enzyme inhibitory activity and blood pressure-lowering function from wheat bran, barley bran or rice bran without addition of protease and amylase and addition of substances harmful to the human body.;SOLUTION: The angiotensin I converting enzyme inhibitor includes a reaction product as an active ingredient that is obtained by mixing at least one of powder raw material selected from the group consisting of wheat seed powder containing wheat bran, barley seed powder containing at least barley bran and rice seed powder containing at least rice bran with water or buffer solution, adjusting the water or buffer solution after the mixing to pH of 3.05-3.95, subjecting a reserve protein to decomposition reaction by the action of endogenous protease at 30-45°C for at least ≥4 hours to give the reaction product. The medicine contains the angiotensin I converting enzyme inhibitor and has blood pressure-lowering effect.;COPYRIGHT: (C)2011,JPO&INPIT
机译:要解决的问题:从麦麸,大麦麸或米糠中经济有效地提供一种具有血管紧张素I转换酶抑制活性和降血压功能的活性成分,而无需添加蛋白酶和淀粉酶以及对人体有害的物质解决方案:血管紧张素I转化酶抑制剂包括作为反应成分的反应产物,该反应产物是通过混合选自包含麦麸的小麦种子粉,至少包含大麦的大麦种子粉中的至少一种粉末原料而获得的麸皮和至少含有米糠的米粉和水或缓冲溶液,混合后调节水或缓冲溶液的pH至3.05-3.95,使储备蛋白在30-45℃下通过内源蛋白酶的作用进行分解反应。的温度至少≥4小时以得到反应产物。该药物含有血管紧张素转换酶抑制剂,具有降血压作用。; COPYRIGHT:(C)2011,JPO&INPIT

著录项

  • 公开/公告号JP2011102300A

    专利类型

  • 公开/公告日2011-05-26

    原文格式PDF

  • 申请/专利号JP20100264688

  • 发明设计人 NOGATA YOICHI;

    申请日2010-11-29

  • 分类号C07K5/06;C12N9/99;A61K36/899;A61P43/00;A61P9/12;C07K5/08;A23L1/305;C12N9/48;

  • 国家 JP

  • 入库时间 2022-08-21 18:23:43

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