首页> 外国专利> Cell-chip system for cell-based assays and micro-sensor array based screening in living cells and tissues, comprises an inlet chamber, a main chamber in whose base area, a cell culture chamber exists with sensor chip, and outlet chamber

Cell-chip system for cell-based assays and micro-sensor array based screening in living cells and tissues, comprises an inlet chamber, a main chamber in whose base area, a cell culture chamber exists with sensor chip, and outlet chamber

机译：用于在活细胞和组织中进行基于细胞的测定和基于微传感器阵列的筛选的细胞芯片系统，包括一个入口室，一个位于其底部区域的主室，一个带有传感器芯片的细胞培养室以及一个出口室

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摘要

The cell-chip system comprises an inlet chamber (12), a main chamber (14) in whose base area, a cell culture chamber (20) exists itself with sensor chip (22) arranged under the cell culture chamber, and an outlet chamber (16). An inlet channel is present between the inlet chamber and the cell culture chamber and an outlet channel with an outlet channel discharge opening is present between the cell culture chamber and the outlet chamber. The base of the outlet chamber comprises a conical depression. The cell-chip system comprises an inlet chamber (12), a main chamber (14) in whose base area, a cell culture chamber (20) exists itself with sensor chip (22) arranged under the cell culture chamber, and an outlet chamber (16). An inlet channel is present between the inlet chamber and the cell culture chamber and an outlet channel with an outlet channel discharge opening is present between the cell culture chamber and the outlet chamber. The base of the outlet chamber comprises a conical depression and the base of the cell culture chamber and/or the outlet chamber lies beneath the outlet channel discharge opening. The depression comprises a volume of 5-300 ul and has an outlet canal over which the depression is deflated. The base of the inlet chamber comprises a bevel well-disposed to the inlet channel. The bevel comprises an inclination of 5-70[deg] .

机译：该细胞芯片系统包括入口室（12），在其底部区域中的主室（14），自身存在的细胞培养室（20）以及布置在细胞培养室下方的传感器芯片（22），以及出口室。（16）。在入口室和细胞培养室之间存在入口通道，并且在细胞培养室和出口室之间存在具有出口通道排出口的出口通道。出口腔室的底部包括一个锥形凹陷。该细胞芯片系统包括入口室（12），在其底部区域中的主室（14），自身存在的细胞培养室（20）以及布置在细胞培养室下方的传感器芯片（22），以及出口室。（16）。在入口室和细胞培养室之间存在入口通道，并且在细胞培养室和出口室之间存在具有出口通道排出口的出口通道。出口腔室的底部包括锥形凹部，并且细胞培养腔室和/或出口腔室的底部位于出口通道排出口的下方。凹部包括5-300ul的体积并且具有出口通道，凹部在其上放气。进气室的底部包括一个斜面，斜面布置在进气通道上。斜面包括5-70°的倾斜度。

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公开/公告号DE102008035646A1

专利类型
公开/公告日2010-02-04

原文格式PDF
申请/专利权人 LOB VOLKER;
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申请/专利号DE20081035646
发明设计人 LOB VOLKER;
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申请日2008-07-31
分类号C12M1/34;G01N35/08;C12M3/04;G01N33/48;G01N21/05;
国家 DE
入库时间 2022-08-21 18:28:53

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