首页> 外国专利> Measuring method for detecting aspirin resistance in blood of healthy and sick people, which before the measurement acetylsalicylic acid is need not to be taken

Measuring method for detecting aspirin resistance in blood of healthy and sick people, which before the measurement acetylsalicylic acid is need not to be taken

机译:检测健康人和病人血液中阿司匹林抗性的测定方法,在测定乙酰水杨酸之前不需要

摘要

Measuring method for detecting aspirin resistance in blood of healthy and sick people, which before the measurement acetylsalicylic acid is need not to be taken, is claimed. Independent claims are included for: (1) measuring aspirin resistance in whole blood that is made with anticoagulants comprising citrate, hirudin or heparin; (2) measuring aspirin resistance in the blood of patients and test persons, whose blood is anticoagulated with heparin; (3) measuring aspirin resistance by the measurement of platelet adhesion in heparin blood, in which the platelet adhesion is influenced by the addition of 10-1000 nmol of aspirin; (4) measuring aspirin resistance by the measurement of platelet adhesion in heparin anticoagulated whole blood of patients and test persons, where the blood is mixed ex vivo preferably with 20-100 nmol of aspirin in comparison with non-aspirin-containing blood sample; and (5) determination of aspirin-induced adhesion index with and without aspirin-treated blood samples and comparing the values for the detection of aspirin resistance.
机译:本发明要求一种用于检测健康人和病人血液中阿司匹林抗性的测量方法,该方法不需要在测量乙酰水杨酸之前进行。包括以下方面的独立权利要求:(1)测量由包含柠檬酸盐,水rud素或肝素的抗凝剂制成的全血中阿司匹林的抗性; (2)测量血液和肝素抗凝剂的患者和测试者血液中的阿司匹林抗性; (3)通过测量肝素血液中的血小板粘附性来测量阿司匹林抗性,其中通过添加10-1000nmol阿司匹林来影响血小板粘附性; (4)通过测量患者和测试者的肝素抗凝全血中血小板粘附性来测量阿司匹林抗性,其中血液与不含阿司匹林的血液样品相比优选离体混合20-100nmol阿司匹林; (5)在有和没有阿司匹林处理的血样的情况下测定阿司匹林诱导的粘附指数,并比较用于检测阿司匹林抗性的值。

著录项

  • 公开/公告号DE102008022189A1

    专利类型

  • 公开/公告日2009-11-19

    原文格式PDF

  • 申请/专利权人 NOWAK GOETZ;

    申请/专利号DE20081022189

  • 发明设计人 NOWAK GOETZ;

    申请日2008-04-30

  • 分类号G01N33/50;G01N33/86;

  • 国家 DE

  • 入库时间 2022-08-21 18:29:01

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