首页> 外国专利> STRAIN OF HYBRID ANIMAL CELLS Mus museums L - PRODUCER OF MONOCLONAL ANTIBODIES FOR EXPOSING NUCLEOPROTEIN OF EBOLA VIRUS, ZAIRE SUBTYPE (Mainga STRAIN) (VERSIONS), MONOCLONAL ANTIBODY PRODUCED BY SAID STRAIN (VERSIONS) AND SET FOR 'SANDWICH' FORMAT IMMUNOENZYMOMETRIC TEST SYSTEM FOR EXPOSING NUCLEOPROTEIN OF EBOLA VIRUS, ZAIRE SUBTYPE (Mainga STRAIN)

STRAIN OF HYBRID ANIMAL CELLS Mus museums L - PRODUCER OF MONOCLONAL ANTIBODIES FOR EXPOSING NUCLEOPROTEIN OF EBOLA VIRUS, ZAIRE SUBTYPE (Mainga STRAIN) (VERSIONS), MONOCLONAL ANTIBODY PRODUCED BY SAID STRAIN (VERSIONS) AND SET FOR 'SANDWICH' FORMAT IMMUNOENZYMOMETRIC TEST SYSTEM FOR EXPOSING NUCLEOPROTEIN OF EBOLA VIRUS, ZAIRE SUBTYPE (Mainga STRAIN)

机译:混合动物细胞株Mus博物馆L-暴露埃博拉病毒,zaire亚型(Mainga菌株)(版本),SAIDSTRUMTS的反义系(版本)生产的单克隆抗体和“为之准备的反义系”的单克隆抗体生产商暴露埃博拉病毒,ZAIRE亚型的核蛋白(Mainga株)

摘要

FIELD: chemistry; biochemistry.;SUBSTANCE: invention discloses a strain of hybrid animal cells Mus musculus L. 1B2, which is deposited in the Collection of cell cultures of the State Research Center of Virology and Biotechnology VECTOR, which is a producer of monoclonal antibodies which are specific to the nucleoprotein of the Ebola virus, Zaire subtype (Mainga strain) and are used as binding antigens in a "sandwich" format immunoenzymometric system for exposing the neucleoprotein of the Ebola virus, Zaire subtype (Mainga strain), and a strain of hybrid animal cells Rattus Norvegicus 7B11 which is deposited in the Collection of cell cultures of the State Research Center of Virology and Biotechnology VECTOR and which is a producer of monoclonal antibodies which are specific to the nucleoprotein of Ebola virus, Zaire subtype (Mainga strain) and are used as biotin labelled indicators in the "sandwich" format immunoenzymometric system for exposing nucleoprotein of the Ebola virus, Zaire subtype (Mainga strain). The invention describes monoclonal antibodies 1B2 which are produced by the strain of hybrid animal cells Mus musculus L. 1B2, which relate to the subclass of immunoglobulins IgGl which have a heavy 55 kDa and a light 25 kDa chain, and monoclonal antibodies 7B11 which are produced by the strain of hybrid animal cells Rattus Norvegicus 7B 11 related to the subclass of immunoglobulins IgG. The antibodies are used together in the "sandwich" format immunoenzymometric system for exposing nucleoprotein of the Ebola virus, Zaire subtype (Mainga strain).;EFFECT: use of the invention enables to obtain results during "ВЭ" laboratory reseach and when designing a test system for highly reliable exposure of an antigen.;5 cl, 3 dwg, 2 tbl, 7 ex
机译:领域:化学;发明内容:本发明公开了一种杂种动物细胞Mus musculus L.1B​​2的菌株,该菌株保藏在国家病毒学和生物技术研究中心VECTOR的细胞培养物保藏中,该细胞培养物是特异于此的单克隆抗体的生产者。埃博拉病毒Zaire亚型(Mainga株)的核蛋白,并在“三明治”格式免疫酶系统中用作结合抗原,用于暴露埃博拉病毒Zaire亚型(Mainga株)的神经蛋白和杂种动物细胞株Rattus Norvegicus 7B11存放在国家病毒与生物技术研究中心VECTOR的细胞培养物中,是单克​​隆抗体的生产者,该单克隆抗体对埃博拉病毒Zaire亚型(Mainga株)的核蛋白具有特异性,可以用作生物素标记的“三明治”式免疫酶系统中的指示剂,用于暴露埃博拉病毒Zaire亚型的核蛋白(Mainga stra在)。本发明描述了由杂交动物细胞Mus musculus L.的菌株产生的单克隆抗体1B2,其涉及具有55kDa重链和25kDa轻链的免疫球蛋白IgG1的亚类,以及产生的单克隆抗体7B11。由杂种动物细胞Rattus Norvegicus 7B 11的菌株引起的与免疫球蛋白IgG亚类有关。抗体在“三明治”格式的免疫酶法系统中一起使用,以暴露埃博拉病毒Zaire亚型(Mainga株)的核蛋白。系统高度可靠地暴露抗原。; 5 cl,3 dwg,2 tbl,7 ex

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