or its pharmaceutically acceptable salt with antagonist activity to corticotrophin release factor (CRF). In formula (I) X means heteroaryl chosen of pyrazolyl and imidazolyl optionally substituted with (C1-C6)alkyl, haloid or phenyl; Y means -NRaRb where Ra means hydrogen, and Rb means phenyl optionally substituted with (C1-C6)alkyl or haloid; Z means (C1-C6)alkyl; and R1 means hydrogen, (C1-C6)alkyl or haloid.;EFFECT: compounds can find application in treatment, eg of neurodegenerative diseases, neuropsychiatric disorders and stresses.;19 cl, 1 dwg, 2 tbl, 4 ex"/>
PIRAZOLOIMIDAZOPYRIMIDINE DERIVATIVES WITH ANTAGONIST ACTIVITY TO CORTICOTROPHIN RELEASE FACTOR (CRF)
首页>
外国专利>
PIRAZOLOIMIDAZOPYRIMIDINE DERIVATIVES WITH ANTAGONIST ACTIVITY TO CORTICOTROPHIN RELEASE FACTOR (CRF)
PIRAZOLOIMIDAZOPYRIMIDINE DERIVATIVES WITH ANTAGONIST ACTIVITY TO CORTICOTROPHIN RELEASE FACTOR (CRF)
展开▼
机译：吡唑并咪唑并嘧啶胺衍生物具有对大肠溶菌素释放因子（CRF）的拮抗活性
展开▼
页面导航
摘要
著录项
相似文献
摘要
FIELD: pharmacology.;SUBSTANCE: invention covers new compounds of formula I: or its pharmaceutically acceptable salt with antagonist activity to corticotrophin release factor (CRF). In formula (I) X means heteroaryl chosen of pyrazolyl and imidazolyl optionally substituted with (C1-C6)alkyl, haloid or phenyl; Y means -NRaRb where Ra means hydrogen, and Rb means phenyl optionally substituted with (C1-C6)alkyl or haloid; Z means (C1-C6)alkyl; and R1 means hydrogen, (C1-C6)alkyl or haloid.;EFFECT: compounds can find application in treatment, eg of neurodegenerative diseases, neuropsychiatric disorders and stresses.;19 cl, 1 dwg, 2 tbl, 4 ex
展开▼
机译：领域：药理学;实质：本发明涵盖式I的新化合物：<图像文件=“ 00000036.GIF” he =“ 31” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 38” />或其药学上可接受的对促肾上腺皮质激素释放因子（CRF）具有拮抗活性的盐。在式（I）中，X表示选自吡唑基和咪唑基的杂芳基，其任选地被（C 1 -C 6 ）烷基，卤素或苯基取代; Y表示-NR a R b ，其中R a 表示氢，R b 表示任选被（ C 1 -C 6 ）烷基或卤素Z是指（C 1 -C 6 ）烷基; R 1 表示氢，（C 1 -C 6 ）烷基或卤素。效果：化合物可用于治疗，例如神经退行性疾病，神经精神疾病和压力。; 19 cl，1 dwg，2 tbl，4 ex
展开▼
