首页> 外国专利> SPECIFIC MARKER GENES FOR DIAGNOSING PREGNANCY-INDUCED HYPERTENSION AND METHODS FOR ANALYZING GENE EXPRESSION LEVELS RELATED TO PREGNANCY-INDUCED HYPERTENSION USING THE SPECIFIC MARKER GENES

SPECIFIC MARKER GENES FOR DIAGNOSING PREGNANCY-INDUCED HYPERTENSION AND METHODS FOR ANALYZING GENE EXPRESSION LEVELS RELATED TO PREGNANCY-INDUCED HYPERTENSION USING THE SPECIFIC MARKER GENES

机译:用于诊断妊娠引起的高血压的特定标记基因,以及使用特定标记基因分析与妊娠引起的高血压相关的基因表达水平的方法

摘要

PURPOSE: A marker gene for specifically diagnosing pregnancy-induced hypertension and a method for analyzing pregnancy-induced hypertension-associated gene expression pattern using the same are provided to accurately predict pregnancy-induced hypertension. CONSTITUTION: A marker gene for specifically diagnosing pregnancy-induced hypertension is OXGR1(GenBank Accession No.: NM_080818), GALK2(GenBank Accession No.: NM_002044) or HBG2(GenBank Accession No.: NM_000184) gene. A method for analyzing pregnancy-induced hypertension-associated expression pattern comprises: a step of preparing RNA from a pregnant woman; a step of synthesizing fluorescence-labeled complementary base seqeuce using the RNA; a step of hybridizing oligonucleotide of OXGR1(GenBank Accession No.: NM_080818), GALK2(GenBank Accession No.: NM_002044) or HBG2(GenBank Accession No.: NM_000184) gene; a step of checking the fluorescence intensity by binding between the complementary base sequene and oligonucleotide; and a step of analyzing the difference of expression level with normal group.
机译:目的:提供一种可特异性诊断妊娠高血压综合征的标记基因,并提供一种利用该基因分析妊娠高血压相关基因表达模式的方法,以准确预测妊娠高血压综合征。组成:专门诊断妊娠高血压综合征的标记基因是OXGR1(GenBank登录号:NM_080818),GALK2(GenBank登录号:NM_002044)或HBG2(GenBank登录号:NM_000184)基因。一种分析妊娠高血压相关表达模式的方法,包括:从孕妇制备RNA的步骤;使用所述RNA合成荧光标记的互补碱基序列的步骤;杂交OXGR1(GenBank登录号:NM_080818),GALK2(GenBank登录号:NM_002044)或HBG2(GenBank登录号:NM_000184)基因的寡核苷酸的步骤;通过互补碱基序列和寡核苷酸之间的结合检查荧光强度的步骤;以及分析表达水平与正常组差异的步骤。

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