APPARATUS FOR VISUALIZING AND ANALYZING GENE EXPRESSION PATTERNS USING GENE ONTOLOGY TREE AND METHOD THEREOF

• 1. 利用卡那霉素抗性基因作为筛选标记对麻疯树进行基因转化的方法 [P] . 中国专利： CN102304543B . 2014.05.28
• 2. 利用卡那霉素抗性基因作为筛选标记对麻疯树进行基因转化的方法 [P] . 中国专利： CN102304543A . 2012-01-04
• 3. APPARATUS FOR VISUALIZING AND ANALYZING GENE EXPRESSION PATTERNS USING GENE ONTOLOGY TREE AND METHOD THEREOF [P] . 世界知识产权组织专利： WO2010018882A1 . 2010-02-18

  机译： 利用基因本体树对基因表达模式进行可视化和分析的装置及其方法

• 4. Apparatus and method for visualizing and analyzing gene expression pattern of biological sample using gene ontology tree [P] . 韩国专利： KR101046689B1 . 2011-07-06

  机译： 利用基因本体树可视化和分析生物样品的基因表达模式的装置和方法

• 5. GENE EXPRESSION LEVEL ANALYZING METHOD, GENE EXPRESSION LEVEL ANALYZING PROGRAM, AND GENE EXPRESSION LEVEL ANALYZING DEVICE [P] . 美国专利： US2010009369A1 . 2010-01-14

  机译： 基因表达水平分析方法，基因表达水平分析程序和基因表达水平分析装置

• 1. A simulation to analyze feature selection methods utilizing gene ontology for gene expression classification [J] . GilliesC.E., SiadatM.-R., PatelN.V., Journal of biomedical informatics. . 2013,第6期
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• 3. mDAG: A web tool for analyzing, visualizing, and interpreting response patterns in gene expression data with multiple treatments [J] . Nam S. Vo, Thomas R. Sutter, Vinhthuy Phan Advances in Bioscience and Biotechnology . 2013,第6期
• 4. A software framework integrating gene expression patterns, binding site analysis and gene ontology to hypothesize gene regulation relationships [C] . Joshi P., Baikang Pei, Seung-Hyun Hong, IEEE International Conference on Bioinformatics and Biomedicine . 2013
• 5. A study of computational methods to analyze gene expression data [D] . Ko, Youn Hee. 2010
• 6. Exploiting the bootstrap method to analyze patterns of gene expression [O] . Nam S Vo, Vinhthuy Phan 2014
• 7. A simulation to analyze feature selection methods utilizing gene ontology for gene expression classification [O] . Gillies Christopher E., Siadat Mohammad-Reza, Patel Nilesh V., 2013

• 1. mDAG: A web tool for analyzing, visualizing, and interpreting response patterns in gene expression data with multiple treatments [J] . Nam S. Vo ,Thomas R. Sutter ,Vinhthuy Phan . 生命科学与技术进展（英文） . 2013,第6期
• 2. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 3. Difference in Nitrogen Starvation-Inducible Expression Patterns among Phylogenetically Diverse Ammonium Transporter Genes in the Red Seaweed iPyropia yezoensis/i [J] . Chengze Li ,Inori Ariga ,Koji Mikami . 美国植物学期刊（英文） . 2019,第8期
• 4. Expression Patterns of CAPN1 and CAPN8b Genes during Embryogenesis in Xenopus laevis [J] . Lucie Abrouk-Vérot ,Claire Brun ,Jean-Marie Exbrayat . 细胞生物学（英文） . 2013,第4期
• 5. Expression patterns and action analysis of genes associated with inflammatory responses during rat liver regeneration [J] . Heng-Yi Shao ,Li-Feng Zhao ,Cun-Shuan Xu . 世界胃肠病学杂志：英文版 . 2007,第3期
• 6. 一种酸解烃制备装置及利用该装置进行酸解烃测定的方法 [C] . 梁前勇 ,赵静 ,熊永强 . 第六届全国油气化探学术会议 . 2012
• 7. 利用RT-PCR方法进行风疹及麻疹病毒的临床检测及基因序列分析 [A] . 时雪梅 . 2007