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SPHINGOLIPID HAVING ENDOPLASMIC RETICULUM LOCALIZATION SIGNAL ATTACHED THERETO, AND METHOD FOR PRODUCTION OF CERAMIDE IN TRANSFORMED CELL USING amp;Delta;4-DESATURASE
SPHINGOLIPID HAVING ENDOPLASMIC RETICULUM LOCALIZATION SIGNAL ATTACHED THERETO, AND METHOD FOR PRODUCTION OF CERAMIDE IN TRANSFORMED CELL USING amp;Delta;4-DESATURASE
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机译:具有附带的内质网定位信号的类脂脂,以及使用Δ4-脱氢酶在转化细胞中生产铈的方法
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摘要
Disclosed is a method for producing human ceramide in a cell such as a yeast cell. The method comprises the following steps 1) and 2): 1) introducing a gene (DES1m) for sphingolipid Δ4-desaturase having an endoplasmic reticulum localization signal attached thereto by the transformation of a yeast cell, wherein the gene (DES1m) comprises sphingolipid Δ4-desaturase gene (DES1) having a nucleotide sequence encoding a yeast endoplasmic reticulum localization signal attached to its 3'-terminus; and 2) causing a loss of the expression of yeast sphinganine C4-hydroxylase gene (SUR2) by the transformation of a yeast cell.;COPYRIGHT KIPO & WIPO 2010
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