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Analysis of the genetic disposition for epidermolysis bullosa in sheep
Analysis of the genetic disposition for epidermolysis bullosa in sheep
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机译：绵羊大疱表皮松解的遗传配置分析
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摘要
The invention provides a method for genetic analysis, which is suitable to predict the individual risk to develop phenotypic JEB, and for the determination of the individual risk for hereditary transmission of an allele causing JEB. The method for genetic analysis can be used on nucleic acid molecules derived from animals, especially sheep. Preferably, the genetic analysis is carried out on total DNA and/or RNA isolated from an individual, e.g. DNA isolated from a blood sample.;The genetic analysis identifies the presence of alleles of genetic markers that have been found to be coupled to JEB. Generally, the analysis comprises the identification of the presence of mutant alleles of genetic markers that have been found to be present in sheep affected by phenotypic JEB, whereas wild-type alleles of the markers have been found to be associated with a non - JEB phenotype or non - JEB predisposition.
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