首页> 外国专利> USE OF HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM METASTASES

USE OF HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM METASTASES

机译:组蛋白去乙酰化酶抑制剂在治疗中枢神经系统转移中的应用

摘要

Disclosed is a method of treating a localized carcinoma central nervous system (CNS) metastasis of extra-CNS origin, the method comprising systemically administering an effective amount of a histone deacetylase (HDAC) inhibitor (HDI) to a subject in need of treatment for the localized carcinoma CNS metastasis of extra-CNS origin. The HDI can be any HDI capable of crossing the blood-brain barrier (BBB) such as vorinostat. The localized carcinoma CNS metastasis of extra-CNS origin can be a localized carcinoma brain metastasis. The localized carcinoma brain metastasis can originate in the breast. The CNS metastasis treated can be a micrometastasis, a brain tumor, or an intervening stage of brain cancer.
机译:公开了一种治疗外CNS起源的局部癌中枢神经系统(CNS)转移的方法,该方法包括向需要治疗的受试者系统性地给予有效量的组蛋白脱乙酰基酶(HDAC)抑制剂(HDI)。中枢神经系统起源的局限性癌中枢神经系统转移。 HDI可以是任何能够穿过血脑屏障(BBB)的HDI,例如伏立诺他。中枢神经系统起源的局灶性癌CNS转移可以是局灶性癌脑转移。局部癌脑转移可起源于乳房。经治疗的CNS转移可以是微转移,脑肿瘤或脑癌的介入阶段。

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