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A METHOD FOR PREPARING THE PRIMERS FOR IN VITRO IDENTIFYING MUTATIONS WITHIN LARGED VESTIBULAR AQUEDUCT SYNDROMIC HEARING LOSS PDS GENE AND THE USE THEREOF
A METHOD FOR PREPARING THE PRIMERS FOR IN VITRO IDENTIFYING MUTATIONS WITHIN LARGED VESTIBULAR AQUEDUCT SYNDROMIC HEARING LOSS PDS GENE AND THE USE THEREOF
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机译：一种制备用于在较大的前庭水肿综合征听力丧失PDS基因中体外鉴定突变的方法及其用途
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摘要
The present invention relates to a method of preparing a primer used for determining the IVS7-2A→G site mutation involved in the large vestibular aqueduct syndrome. The method comprises the steps of : designing a primer pair which may introduce any base substitutive mutation in the region of 1-13 bases between upstream and downstream including the IVS7-2 mutation site (A→G) based upon the IVS7-2 A→ G mutation site in the PDS gene, so as to obtain a new restriction site which may be used for distinguishing IVS7-2 wild type A site and mutant G site in the amplification products. The present invention further relates to the primers prepared according to this method, the kit or reagent or identical product comprising the primers, and a method for determining the IVS7-2A→G site mutation of large vestibular aqueduct syndrome with said primers in vitro.
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