首页> 外国专利> NOVEL PEPTIDE FOR AUGMENTING BRAIN-DERIVED NEUTROTROPHIC FACTOR (BDNF) PROTEIN EXPRESSION IN HIPPOCAMPAL NEURONS, HIPPOCAMPAL TISSUE AND CEREBRAL-CORTEX TISSUE

NOVEL PEPTIDE FOR AUGMENTING BRAIN-DERIVED NEUTROTROPHIC FACTOR (BDNF) PROTEIN EXPRESSION IN HIPPOCAMPAL NEURONS, HIPPOCAMPAL TISSUE AND CEREBRAL-CORTEX TISSUE

机译：新型肽可增强海马神经元，海马组织和脑皮质组织中脑源性中性养分因子（BDNF）蛋白的表达

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摘要

The present invention relates to a novel peptide for augmenting brain-derived neutrotrophic factor (BDNF) protein expression. More specifically, the present invention provides a novel peptide which can be used to prevent or treat neurological disorders such as Alzheimer's disease, Parkinson's disease, depression, stroke, Huntington's chorea, ischaemic disorders of the cerebrum, degenerative neurological disorders or diabetic neural disorders, by augmenting BDNF mRNA and protein expression in hippocampal and cerebral cortical tissue. A Methionine-Valine-Glycine (MVG) peptide comprising three different amino acids of the present invention augmented BDNF mRNA and protein expression in hippocampal neurons, hippocampal tissue and cerebral-cortex tissue; BDNF being an important functional substance in learning and memory, dopamine neuron protection and depression prevention.

机译：本发明涉及用于增强脑源性中性营养因子（BDNF）蛋白表达的新型肽。更具体地说，本发明提供了一种新的肽，该肽可通过以下方法用于预防或治疗神经系统疾病，例如阿尔茨海默氏病，帕金森氏病，抑郁症，中风，亨廷顿舞蹈病，大脑缺血性疾病，变性神经系统疾病或糖尿病性神经疾病。增强BDNF mRNA和蛋白在海马和大脑皮层组织中的表达。包含本发明的三种不同氨基酸的蛋氨酸-缬氨酸-甘氨酸（MVG）肽增强了海马神经元，海马组织和大脑皮质组织中的BDNF mRNA和蛋白表达; BDNF是学习和记忆，多巴胺神经元保护和预防抑郁的重要功能性物质。

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公开/公告号WO2009136752A9

专利类型
公开/公告日2010-01-28

原文格式PDF
申请/专利权人 SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION;KIM KILL YONG;MOON SUNG AH;KIM HONG GI;JUNG WOO RAM;LEE BYOUNG JU;SHIN MIN KYOO;
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申请/专利号WO2009KR02421
发明设计人 KIM HONG GI;MOON SUNG AH;KIM KILL YONG;JUNG WOO RAM;LEE BYOUNG JU;SHIN MIN KYOO;
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申请日2009-05-08
分类号C07K5/00;
国家 WO
入库时间 2022-08-21 18:41:05

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