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ATMOSPHERIC AND VACUUM PRESSURE MALDI ION SOURCE
ATMOSPHERIC AND VACUUM PRESSURE MALDI ION SOURCE
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机译：大气和真空马尔代离子源
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摘要
A Matrix Assisted Laser Desorption Ionization (MALDI) Source (1) operated atatmospheric or vacuum pressure is interfaced to a multipole ion guide (8) orion funnel with alternating current "AC or RF" waveforms applied. Themultipole ion guides (8, 68) or ions funnels are configured to focustransport, trap and/or separate ions produced from a MALDI ion source (1) anddirect the MALDI produced ions to a mass analyzer (3) for MS or MS/MSn mass tocharge analysis. The MALDI sample targets (4) can be positioned at theentrance of a multipole ion guide (8) or ion funnel with gas flow (14) andelectric fields configured to direct ions efficiently into the ion guide (8)or ion funnel. Ions produced by MALDI (1) operated at atmospheric orintermediate vacuum pressures experience ion to neutral gas collisions as theyare transported in the multipole ion guide (8) or ion funnel in the presenceof RF electric fields. The gas collisions serve to damp the ion trajectoriestoward the ion centerline, improving ion transport efficiency into and throughvacuum. Ion mobility and mass to charge separation of ions can be performed inthe multipole ion guide and ion funnel devices while transporting and focusingions.
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